Evidence map›Paper›PMID 38975935›Full record

ArticleAging2024

Sevoflurane impedes neuropathic pain by maintaining endoplasmic reticulum stress and oxidative stress homeostasis through inhibiting the activation of the PLCγ/CaMKII/IP3R signaling pathway.

An Xie, Xianjie Zhang, Feng Ju, Yukai Zhou, Dan Wu, Jia Han

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

An XieDepartment of Anesthesiology, People’s Hospital of Deyang, Deyang, Sichuan, China.
Xianjie ZhangDepartment of Anesthesiology, People’s Hospital of Deyang, Deyang, Sichuan, China.
Feng JuDepartment of Anesthesiology, People’s Hospital of Deyang, Deyang, Sichuan, China.
Yukai ZhouDepartment of Anesthesiology, People’s Hospital of Deyang, Deyang, Sichuan, China.
Dan WuDepartment of Anesthesiology, People’s Hospital of Deyang, Deyang, Sichuan, China.
Jia HanDepartment of Anesthesiology, People’s Hospital of Deyang, Deyang, Sichuan, China.

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectiveTo investigate the effect of sevoflurane on neuropathic pain induced by chronic constriction injury (CCI) of sciatic nerve in mice, and to elucidate its mechanism by animal experiments. METHODS AND

resultsThirty-two C57BL/6 mice were randomly divided into four groups: Sham group, Model group, Control group and Sevoflurane group. First, a mouse model of neuropathic pain was established. Then, the mice in each group were killed on Day 14 after operation to harvest the enlarged lumbosacral spinal cord. In contrast with the Model group, the Sevoflurane group displayed a significantly increased paw withdrawal mechanical threshold (PWMT) and significantly prolonged paw withdrawal thermal latency (PWTL) from Day 5 after operation. The morphological changes of lumbosacral spinal cord were observed by hematoxylin-eosin (HE) staining and transmission electron microscopy. Pathological results showed that sevoflurane reduced nuclear pyknosis in lumbosacral spinal cord tissue, with a large number of mitochondrial crista disappearance and mitochondrial swelling. The results of Western blotting showed that sevoflurane significantly decreased the protein expressions of phosphorylated phospholipase Cγ (p-PLCγ), phosphorylated calcium/calmodulin-dependent protein kinase II (p-CaMKII) and phosphorylated inositol 1,4,5-triphosphate receptor (p-IP3R), and reduced the protein expressions of endoplasmic reticulum (ER) stress proteins glucose-regulated protein 78 (GRP78) and GRP94, oxidative stress-related proteins P22 and P47 and inflammatory factors nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3), interleukin-1 β (IL-1β), and tumor necrosis factor-α (TNF-α).

conclusionsSevoflurane inhibits neuropathic pain by maintaining ER stress and oxidative stress homeostasis through inhibiting the activation of the PLCγ/CaMKII/IP3R signaling pathway.

Indexed as

Calcium-Calmodulin-Dependent Protein Kinase Type 2Endoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressInositol 1,4,5-Trisphosphate ReceptorsMice, Inbred C57BLNeuralgiaOxidative StressPhospholipase C gammaSevofluraneSignal TransductionAnimalsDisease Models, AnimalHomeostasisMaleMiceSciatic NerveCalcium-Calmodulin-Dependent Protein Kinase Type 2Endoplasmic Reticulum Chaperone BiPHspa5 protein, mouseInositol 1,4,5-Trisphosphate ReceptorsPhospholipase C gammaSevofluranecalcium influxchronic constriction injury of sciatic nerveneuropathic painoxidative stresssevoflurane

Identifiers

PMID38975935
PMCPMC11272110

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.