ArticleFrontiers in public health2024
The association of physical activity and sedentary behavior with depression in US adults: NHANES 2007-2018.
Article in Frontiers in public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Role of Digital Biomarkers in Physiological Signal-Based Depression Assessment: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2026Pooled it
- Depression meets obesity: Co-occurrence patterns, temporal trends and socioeconomic correlates across 199 countries and territories.General psychiatry · 2026Article
- Nonlinear Association of Daily Sitting Time With Depression Risk in US Adults: A Cross-Sectional Study.Behavioural neurology · 2026Article
- Compositional Associations of 24-h Movement Behaviors With Depressive and Anxiety Symptoms in Middle-Aged Adults.Depression and anxiety · 2026Article
- BMI partially mediates the association between the non-HDL-C/HDL-C ratio and depression in obese adults.Diabetology & metabolic syndrome · 2025Article
- Article
- Physical Activity and Psychological Symptoms in University Teachers Improved Post-COVID-19 Lockdown, but Sedentary Behavior Persisted.Healthcare (Basel, Switzerland) · 2025Article
- The association between physical activity and depression among weekend catch-up sleepers: results from NHANES 2021-2023.BMC psychiatry · 2025Article
- Positive and linear association of hepatic steatosis index with female infertility in US women: results from the National Health and Nutrition Examination Survey 2013-2018.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Depression is largely preventable, and strategies that can effectively suppress its development are imperative. We aimed to examine whether physical activity and sedentary behavior were associated with depression and explore the possible mediatory role of complete blood count in this association. Methods: In this cross-sectional study, data were integrated from the National Health and Nutrition Examination Study (2007-2018). Depression was defined using the Patient Health Questionnaire-9. The risk for depression, expressed as odds ratio (OR) and 95% confidence interval (CI), was quantified by survey-weighted logistic regression analyses. Results: A total of 31,204 respondents were analyzed. Significance was identified for all, except walking or bicycling per week, types of physical activity, and sedentary behavior. Per 1 standard deviation (SD) increment in metabolic equivalent of task (MET) of weekly vigorous recreational physical activity was associated with 31.3% decreased depression risk (adjusted OR: 0.687, 95% CI: 0.5663-0.840). Per 1 SD increment in sitting time can increase depression risk by 22.4% (adjusted OR: 1.224, 95% CI: 1.131-1.325). In subsidiary analyses, the association with depression was reinforced in respondents aged ≤65 years and those overweight or obese. Mediation analyses revealed significant effects for red blood cell (RBC) on total MET (19.4%) and moderate work-related physical activity (MWPA) (22.0%), and for red cell distribution wide (RCDW) on vigorous work-related physical activity (17.7%), moderate work-related physical activity (13.1%), total MET (11.2%), and sitting time (16.4%) ( Conclusion: Our findings indicate that more physical activity and less sitting time were associated with a lower likelihood of having depression among US adults, and this association was probably mediated by RBC and RCDW.
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