Evidence map›Paper›PMID 38975323›Full record

ArticleFrontiers in cellular and infection microbiology2024

No evidence on infectious DNA-based agents in pediatric acute lymphoblastic leukemia using whole metagenome shotgun sequencing.

Amadeus T Heinz, Silke Grumaz, Christoph Slavetinsky, Michaela Döring, Manon Queudeville, Rupert Handgretinger, Martin Ebinger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amadeus T HeinzDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Tuebingen, Tuebingen, Germany.
Silke GrumazNoscendo GmbH, Duisburg, Germany.
Christoph SlavetinskyDepartment of Pediatric Surgery and Urology, University Children´s Hospital Tuebingen, Tuebingen, Germany.
Michaela DöringDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Tuebingen, Tuebingen, Germany.
Manon QueudevilleDepartment for Stem Cell Transplantation and Immunology, Klinikum Hamburg-Eppendorf (UKE), Hamburg, Germany.
Rupert HandgretingerAbu Dhabi Stem Cells Center, Abu Dhabi, United Arab Emirates.
Martin EbingerDepartment of Pediatric Hematology and Oncology, University Children´s Hospital Tuebingen, Tuebingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The etiology of pediatric acute lymphatic leukemia (ALL) is still unclear. Whole-metagenome shotgun sequencing of bone marrow samples in patients with treatment-naïve ALL (n=6) was performed for untargeted investigation of bacterial and viral DNA. The control group consisted of healthy children (n=4) and children with non-oncologic diseases (n=2) undergoing bone marrow sampling. Peripheral blood of all participants was investigated at the same time. After bioinformatical elimination of potential contaminants by comparison with the employed controls, no significant amounts of microbial or viral DNA were identified.

Indexed as

DNA, ViralMetagenomePrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentBacteriaBone MarrowChildChild, PreschoolDNA, BacterialFemaleHumansMaleMetagenomicsSequence Analysis, DNADNA, BacterialDNA, ViralALLhigh-throughput sequencinginfectious etiologymicrobiomeshotgun sequencing

Identifiers

PMID38975323
PMCPMC11224432

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.