Evidence map›Paper›PMID 38975228›Full record

ReviewHeliyon2024

Inspiring a convergent engineering approach to measure and model the tissue microenvironment.

Rishyashring R Iyer, Catherine C Applegate, Opeyemi H Arogundade, Sushant Bangru, Ian C Berg, Bashar Emon, Marilyn Porras-Gomez, Pei-Hsuan Hsieh, Yoon Jeong, Yongdeok Kim and 12 more

Abstract readReview
In one paragraph

Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Rishyashring R IyerDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Catherine C ApplegateDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Opeyemi H ArogundadeDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Sushant BangruDepartment of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Ian C BergDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Bashar EmonDepartment of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Marilyn Porras-GomezDepartment of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Pei-Hsuan HsiehDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Yoon JeongDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Yongdeok KimDepartment of Materials Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Hailey J KnoxDepartment of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Amir Ostadi MoghaddamDepartment of Mechanical Science and Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Carlos A RenteriaDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Craig RichardDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Ashlie Santaliz-CasianoDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Sourya SenguptaDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Jason WangDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Samantha G ZambutoDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Maria A ZeballosDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Marcia PoolDepartment of Bioengineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
Rohit BhargavaDepartment of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.
H Rex GaskinsDivision of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, IL, 61801, USA.

Funding

Tissue microenvironment (TIMe) training programT32EB019944 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BHARGAVA, ROHIT, GASKINS, REX · 2016 to 2025
$1.9M
NIBIB NIH HHS T32 EB019944
6 · The paper itself

Abstract

Understanding the molecular and physical complexity of the tissue microenvironment (TiME) in the context of its spatiotemporal organization has remained an enduring challenge. Recent advances in engineering and data science are now promising the ability to study the structure, functions, and dynamics of the TiME in unprecedented detail; however, many advances still occur in silos that rarely integrate information to study the TiME in its full detail. This review provides an integrative overview of the engineering principles underlying chemical, optical, electrical, mechanical, and computational science to probe, sense, model, and fabricate the TiME. In individual sections, we first summarize the underlying principles, capabilities, and scope of emerging technologies, the breakthrough discoveries enabled by each technology and recent, promising innovations. We provide perspectives on the potential of these advances in answering critical questions about the TiME and its role in various disease and developmental processes. Finally, we present an integrative view that appreciates the major scientific and educational aspects in the study of the TiME.

Indexed as

BioengineeringBioimagingBiomaterialsBiomedical devicesBiosensingBiotechnologyComputational biologyInterdisciplinary research

Identifiers

PMID38975228
PMCPMC11226808

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.