Evidence map›Paper›PMID 38975122›Full record

ArticleHeliyon2024

BCG vaccination is associated with longitudinal changes in systemic eicosanoid levels in elderly individuals: A secondary outcome analysis.

Pavan Kumar Nathella, Chandrasekaran Padmapriyadarsini, Arul Nancy, Kushiyasri Karunanithi, Nandhini Selvaraj, Rachel Mariam Renji, B M Shrinivasa, Subash Babu

Registry-linked trialAbstract read
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In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04475302 (Study to Evaluate the Effectiveness of BCG Vaccine in Reducing Morbidity and Mortality in Elderly Individuals in COVID-19 Hotspots in India), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04475302 phase3completednot on this map

Study to Evaluate the Effectiveness of BCG Vaccine in Reducing Morbidity and Mortality in Elderly Individuals in COVID-19 Hotspots in India

TypeinterventionalSponsorTuberculosis Research Centre, IndiaRan2020 to 2021Enrolled2,175ConditionsCOVIDArmsBCG vaccine (Freeze-dried)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pavan Kumar NathellaICMR-National Institute for Research in Tuberculosis, Chennai, India.
Chandrasekaran PadmapriyadarsiniICMR-National Institute for Research in Tuberculosis, Chennai, India.
Arul NancyICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India.
Kushiyasri KarunanithiICMR-National Institute for Research in Tuberculosis, Chennai, India.
Nandhini SelvarajICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India.
Rachel Mariam RenjiICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India.
B M ShrinivasaICMR-National Institute for Research in Tuberculosis, Chennai, India.
Subash BabuICMR-National Institute for Research in Tuberculosis-International Center for Excellence in Research, Chennai, India.

Funding

India International Center for Excellence in ResearchZIAAI001065 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI NUTMAN, THOMAS · 2009 to 2025
$19.0M
6 · The paper itself

Abstract

We investigated how BCG vaccination affects the levels of certain eicosanoids, namely Leukotriene B4, 15-epimer of LXA4, prostaglandin F2, Lipoxin A4, Prostaglandin E2 and Resolvin D1 in the plasma of healthy elderly individuals (aged 60-80) before vaccination, one month post-vaccination (M1), and six months post-vaccination (M6). This study is part of the clinical trial "BCG Vaccine Study: Reducing COVID-19 Impact on the Elderly in Indian Hotspots," registered in the clinical trial registry (NCT04475302). While some primary outcomes have been previously reported, this analysis delves into the immunological outcomes. Our findings indicate that BCG vaccination leads to reduced plasma levels of 15-

Indexed as

BCGEicosanoidsInflammationLeukotrienesLipoxinsProstaglandinsVaccines

Identifiers

PMID38975122
PMCPMC11226842

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.