Abnormal activation of genomic LINE1 elements caused by DNA demethylation contributes to lncRNA CASC9 overexpression in esophageal squamous cell carcinoma.

Xuedan Chen, Juan Li, Xingying Guan, Yun Bai, Kai Wang

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Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Xuedan ChenDepartment of Medical Genetics, Department of Basic Medicine, Army Medical University, Chongqing 400038, China.

Juan LiDepartment of Medical Genetics, Department of Basic Medicine, Army Medical University, Chongqing 400038, China.

Xingying GuanDepartment of Medical Genetics, Department of Basic Medicine, Army Medical University, Chongqing 400038, China.

Yun BaiDepartment of Medical Genetics, Department of Basic Medicine, Army Medical University, Chongqing 400038, China.

Kai WangDepartment of Medical Genetics, Department of Basic Medicine, Army Medical University, Chongqing 400038, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long noncoding RNA (lncRNA) cancer susceptibility 9 (CASC9) has been found to be overexpressed and functions as an oncogene in many cancer types. We investigated the molecular mechanism underlying CASC9 overexpression in esophageal squamous cell carcinoma (ESCC). Transcripts containing exons 2 and 6 and exons 4 and 6 showed the highest CASC9 expression levels in ESCC, no transcripts were detected in the normal esophageal epithelial Het1A cell line. The Long Interspersed Nuclear Element-1 (LINE1 or L1) element in the genome was found to participate in the evolution of lncRNA CASC9, the antisense promoter (ASP) of L1 provides the

Identifiers

PMID38975080

DOI10.1016/j.heliyon.2024.e32857

PMCPMC11226909

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