Evidence map›Paper›PMID 38974964›Full record

ArticleiScience2024

Pleiotropic brain function of whirlin identified by a novel mutation.

Carlos Aguilar, Debbie Williams, Ramakrishna Kurapati, Rasneer S Bains, Philomena Mburu, Andy Parker, Jackie Williams, Danilo Concas, Hilda Tateossian, Andrew R Haynes and 20 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Carlos AguilarMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Debbie WilliamsMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Ramakrishna KurapatiMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Rasneer S BainsMary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Philomena MburuMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Andy ParkerMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Jackie WilliamsMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Danilo ConcasMary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Hilda TateossianMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Andrew R HaynesMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Gareth BanksMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Pratik VikheMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Ines HeiseMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Marie HutchisonMary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Gemma AtkinsMary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Simon GillardMary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Becky StarbuckMary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Simona OliveriMary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Andrew BlakeMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Siddharth SethiMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Saumya KumarMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Tanaya BardhanSchool of Biosciences, University of Sheffield, Sheffield, South Yorkshire S10 2TN, UK.
Jing-Yi JengSchool of Biosciences, University of Sheffield, Sheffield, South Yorkshire S10 2TN, UK.
Stuart L JohnsonSchool of Biosciences, University of Sheffield, Sheffield, South Yorkshire S10 2TN, UK.
Lara F CornsSchool of Biosciences, University of Sheffield, Sheffield, South Yorkshire S10 2TN, UK.
Walter MarcottiSchool of Biosciences, University of Sheffield, Sheffield, South Yorkshire S10 2TN, UK.
Michelle SimonMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Sara WellsMary Lyon Centre at MRC Harwell, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Paul K PotterMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.
Heena V LadMRC Harwell Institute, Mammalian Genetics Unit, Harwell Campus, Didcot, Oxfordshire OX11 0RD, UK.

Funding

Wellcome Trust 224326
6 · The paper itself

Abstract

Despite some evidence indicating diverse roles of whirlin in neurons, the functional corollary of whirlin gene function and behavior has not been investigated or broadly characterized. A single nucleotide variant was identified from our recessive ENU-mutagenesis screen at a donor-splice site in whirlin, a protein critical for proper sensorineural hearing function. The mutation (

Indexed as

Biological sciencesMolecular neuroscienceNeuroscience

Identifiers

PMID38974964
PMCPMC11225360

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.