ArticleiScience2024
Single-cell view into the role of microbiota shaping host immunity in the larynx.
Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Microbiota and head and neck cancers: Mechanistic insights and translational potential.Virulence · 2026Review
- Influenza A virus infection induces initial proliferation of commensalJournal of virology · 2026Article
- Comparison between a conventional tool and deep learning models for RNA velocity analysis of scRNA-Seq data.Molecular genetics and genomics : MGG · 2026Article
- Identification of stem cell marker-positive subpopulations in the vocal fold of the larynx through transcriptomic analyses.Nature communications · 2026Article
- A non-canonical role ofbioRxiv : the preprint server for biology · 2026Article
- Article
- Gut-larynx axis and its contribution to laryngeal immunity.mSystems · 2025Article
- Toll Like Receptors in the Larynx: Implications for Laryngeal Immunology.The Laryngoscope · 2025Article
- Cellular heterogeneity and patterning strategies as revealed by upper respiratory epithelium single cell atlas.iScience · 2025Article
- Effects of psychosocial stress on laryngeal microbiology and epithelial barrier integrity.Scientific reports · 2025Article
- Biophysical aspects of mechanotransduction in cells and their physiological/biological implications in vocal fold vibration: a narrative review.Frontiers in cell and developmental biology · 2025Review
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Microbiota play a critical role in the development and training of host innate and adaptive immunity. We present the cellular landscape of the upper airway, specifically the larynx, by establishing a reference single-cell atlas, while dissecting the role of microbiota in cell development and function at single-cell resolution. We highlight the larynx's cellular heterogeneity with the identification of 16 cell types and 34 distinct subclusters. Our data demonstrate that commensal microbiota have extensive impact on the laryngeal immune system by regulating cell differentiation, increasing the expression of genes associated with host defense, and altering gene regulatory networks. We uncover macrophages, innate lymphoid cells, and multiple secretory epithelial cells, whose cell proportions and expressions vary with microbial exposure. These cell types play pivotal roles in maintaining laryngeal and upper airway health and provide specific guidance into understanding the mechanism of immune system regulation by microbiota in laryngeal health and disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.