Evidence map›Paper›PMID 38974465›Full record

ArticleiScience2024

Cbl and Cbl-b ubiquitin ligases are essential for intestinal epithelial stem cell maintenance.

Neha Zutshi, Bhopal C Mohapatra, Pinaki Mondal, Wei An, Benjamin T Goetz, Shuo Wang, Sicong Li, Matthew D Storck, David F Mercer, Adrian R Black and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Neha ZutshiEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Bhopal C MohapatraEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Pinaki MondalDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Wei AnEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Benjamin T GoetzEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Shuo WangDepartment of Radiation Oncology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Sicong LiDepartment of Radiation Oncology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Matthew D StorckEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
David F MercerDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Adrian R BlackEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Sarah P ThayerDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Jennifer D BlackEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Chi LinDepartment of Radiation Oncology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Vimla BandDepartment of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Hamid BandEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Funding

UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI James Eudy · 1985 to 2026
$55.0M
CHEMICAL CARCINOGENESIS &CANCER BIOLOGYT32CA009476 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Jennifer D. Black · 1988 to 2026
$6.2M
MOLECULAR CONTROL OF EGF RECEPTOR DOWN-REGULATIONR01CA099163 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAND, HAMID · 2003 to 2012
$3.7M
Targeting Endocytic Recycling of EGF Receptor in Cancer R01CA105489 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAND, HAMID · 2004 to 2014
$3.0M
NCI NIH HHS P30 CA036727NCI NIH HHS R01 CA099163NCI NIH HHS R01 CA105489NCI NIH HHS T32 CA009476
6 · The paper itself

Abstract

Receptor tyrosine kinases (RTKs) control stem cell maintenance vs. differentiation decisions. Casitas B-lineage lymphoma (CBL) family ubiquitin ligases are negative regulators of RTKs, but their stem cell regulatory roles remain unclear. Here, we show that Lgr5+ intestinal stem cell (ISC)-specific inducible

Indexed as

BiochemistryBiological sciencesCell biologyMolecular biologyNatural sciencesStem cells research

Identifiers

PMID38974465
PMCPMC11225835

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.