Evidence map›Paper›PMID 38974252›Full record

ArticleAfrican health sciences2023

Performance of two SARS-CoV-2 rapid antigen detection tests in resource limited settings, the case of Mali.

Diallo Fatimata, Diarra Bassirou, Sarro Yeya Dit Sadio, Tolofoudie Mohamed, Toure Mahamoudou, Diallo Dramane, Togo Antieme Congo Georges, Bane Sidy, Abdou Mohamed, Konate Mama Sy and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in African health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Diallo FatimataUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Diarra BassirouUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Sarro Yeya Dit SadioUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Tolofoudie MohamedUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Toure MahamoudouUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Diallo DramaneUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Togo Antieme Congo GeorgesUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Bane SidyUniversity of Sciences Techniques and Technologies of Bamako, Laboratory of Virology (LV).
Abdou MohamedNational Institute of Public Health (INSP), Hippodrome, Bamako, Mali, Laboratory and Biomedical Research.
Konate Mama SyMinistry of Health and Social Development, Bamako, Mali, Health Referral Center Six.
Dicko Abdoul RazakouMinistry of Health and Social Development, Bamako, Mali, Health Referral Center Four.
Guindo IbrehimaNational Institute of Public Health (INSP), Hippodrome, Bamako, Mali, Laboratory and Biomedical Research.
Saliba Katy ShawDivision of Clinical Research, NIAID/NIH, Bethesda, MD, USA, Collaborative Clinical Research Branch.
Kone AmadouUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Mamadou DiakiteUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).
Doumbia SeydouUniversity of Sciences Techniques and Technologies of Bamako, University Clinical Research Center (UCRC).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: While real-time reverse transcription PCR (RT-PCR) is the recommended laboratory method to diagnose severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, its use in resource limited settings can be difficult to maintain due to high testing demand and shortage of reagents. The aim of this study was to evaluate the performances of Realy Tech™ and Standard Q™ in comparison to RT-PCR in a relatively low COVID-19 prevalence setting, Mali. Methods: We conducted a cross-sectional study between January and April 2021 in Bamako and Kati regions to evaluate both rapid tests during a large SARS-CoV-2 prevalence study in Mali. Results: Of the 390 samples tested, the sensitivity and specificity of Realy Tech™ and Standard Q™ were 57.1% (95%CI: 44.1-69.2), 95.8% (95%CI: 93.1-97.5); 61.9% (95%CI: 46.8-75.0), and 94.1% (95%CI: 89.5-96.8) respectively. Using RT-PCR, the global prevalence of SARS-CoV-2 was 14.4% (56/390). In both rapid antigen tests, the performance was better when used in suspected patients compared to positive patients under treatment. Moreover, higher viral loads equivalent to Ct < 25 were associated with better detection rates. Conclusion: While waiting for more complete data, these preliminary studies suggest that Realy Tech™ and Standard Q™ should not be used alone for COVID-19 diagnosis in Mali.

Indexed as

COVID-19SARS-CoV-2Sensitivity and SpecificityAdultAntigens, ViralCOVID-19 Nucleic Acid TestingCOVID-19 Serological TestingCOVID-19 TestingCross-Sectional StudiesFemaleHumansMaleMaliPrevalenceReal-Time Polymerase Chain ReactionResource-Limited SettingsAntigens, Viralperformancerapid antigen testsSARS-CoV-2

Identifiers

PMID38974252
PMCPMC11225473

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.