Evidence map›Paper›PMID 38974096›Full record

ArticleBMJ open sport & exercise medicine2024

Obesity is associated with muscle atrophy in rotator cuff tear.

Simone D Herzberg, Zhiguo Zhao, Thomas H Freeman, Ravi Prakash, Keith M Baumgarten, Julie Y Bishop, James L Carey, Grant L Jones, Eric C McCarty, Edwin E Spencer and 14 more

Erratum issuedAbstract read
In one paragraph

Article in BMJ open sport & exercise medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Simone D HerzbergEpidemiology, Vanderbilt University, Nashville, Tennessee, USA.ORCID 0000-0001-9971-9821
Zhiguo ZhaoDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Thomas H FreemanGreat Lakes Orthopaedic Center, Traverse City, Michigan, USA.
Ravi PrakashDepartments of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, Michigan, USA.
Keith M BaumgartenOrthopedic Institute of Sioux Falls, Sioux Falls, South Dakota, USA.
Julie Y BishopDepartments of Orthopaedic Surgery and Sports Medicine, Ohio State University, Columbus, Ohio, USA.
James L CareyDepartment of Orthopaedic Surgery, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Grant L JonesDepartments of Orthopaedic Surgery and Sports Medicine, Ohio State University, Columbus, Ohio, USA.
Eric C McCartyDepartment of Orthopedic Sports Medicine, University of Colorado Denver, Denver, Colorado, USA.
Edwin E SpencerShoulder & Elbow Division, Knoxville Orthopaedic Clinic, Knoxville, Tennessee, USA.
Armando F VidalSteadman Philippon Research Institute, Vail, Colorado, USA.
Nitin B JainPM&R and Orthopaedics, University of Michigan-Ann Arbor, Ann Arbor, Michigan, USA.ORCID 0000-0002-4362-8522
Ayush GiriDivision of Epidemiology, Department of Medicine Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
John E KuhnOrthopaedics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Michael S KhazzamDepartment of Orthopedic Surgery, The University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Elizabeth G MatzkinOrthopedics, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-8592-7187
Robert H BrophyOrthopaedic Surgery, Washington University in Saint Louis School of Medicine, Chesterfield, Missouri, USA.ORCID 0000-0002-2912-8265
Warren R DunnDepartment of Clinical Research, Fondren Orthopedic Group LLP, Houston, Texas, USA.
C Benjamin MaDepartment of Orthopedic Surgery, University of California San Francisco, San Francisco, California, USA.
Robert G MarxHospital for Special Surgery, New York, New York, USA.
Sourav K PoddarDepartment of Orthopedic Sports Medicine, University of Colorado Denver, Denver, Colorado, USA.
Matthew V SmithOrthopaedic Surgery, Washington University in Saint Louis School of Medicine, Chesterfield, Missouri, USA.
Brian R WolfOrthopedics and Rehabilitation, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
Rick W WrightOrthopaedics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3M
Medical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8M
The Genetic Epidemiology of Rotator Cuff Tears: the cuffGEN Study - SupplementR01AR074989 · NIAMS · UT SOUTHWESTERN MEDICAL CENTER · PI JAIN, NITIN B · 2020 to 2025
$3.6M
Investigating Causal Relationships of Diabetes and Obesity on Degenerative Rotator Cuff TearF31AR082662 · NIAMS · VANDERBILT UNIVERSITY · PI HERZBERG, SIMONE · 2023 to 2025
$131k
NIAMS NIH HHS F31 AR082662NIAMS NIH HHS R01 AR074989NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM152284
6 · The paper itself

Abstract

Objective: The primary goal of this study is to evaluate the relationship between Body Mass Index (BMI) and muscle atrophy in individuals with rotator cuff tears. Methods: This study consists of patients with rotator cuff tears identified by MRI from two independent cohorts, the Rotator Cuff Outcomes Workgroup (ROW) and the Multicenter Orthopaedic Outcomes Network (MOON). Presence of atrophy (yes/no) and severity of atrophy (as an ordinal variable) were assessed on MRI by expert physicians. We used multivariable regression models to evaluate the relationship between BMI and muscle atrophy while adjusting for age and sex in each study, conducted sensitivity analyses for full-thickness tear and combined results using inverse variance-weighted meta-analysis. Results: A total of 539 patients (MOON=395, ROW=144) from the combined cohorts had MRI data available on muscle atrophy. Among these patients, 246 (46%) had atrophy of at least one of the muscles of the rotator cuff and 282 (52%) had full-thickness tears. In meta-analysis across both cohorts, each 5 kg/m Conclusions: Higher BMI was associated with significantly higher odds of muscle atrophy in patiens with rotator cuff tears. More study is needed to unders1tand why and how this relationship exists, as well as whether interventions to reduce BMI may help improve outcomes for these patients. Level of Evidence: III.

Indexed as

Adaptations of skeletal muscle to exercise and altered neuromuscular activityMuscle damage/injuriesMuscle injury and inflammationShoulderTendinopathy

Identifiers

PMID38974096
PMCPMC11227827

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.