ArticleJournal of hepatocellular carcinoma2024
Limited Generalizability of Retrospective Single-Center Cohort Study in Comparison to Multicenter Cohort Study on Prognosis of Hepatocellular Carcinoma.
Article in Journal of hepatocellular carcinoma, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
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- Perineural invasion is a prognostic factor in cholangiocarcinoma, regardless of anatomical location: A systematic review and meta-analysis.JHEP reports : innovation in hepatology · 2026Article
- Comments on "Abdominoplasty After Weight Loss in Post-bariatric Surgery: An Optimized Surgery Procedure and Clinical Protocol-A Large Single-Center Study".Aesthetic plastic surgery · 2026Article
- Early postoperative behavioral adherence is associated with recovery efficiency in older adults undergoing colorectal cancer surgery.BMC surgery · 2026Article
- Comparative Analysis of Prescriptions and Pharmacy Services in Internet-Based Psychiatric Hospital During and After the COVID-19 Pandemic: Retrospective Cross-Sectional Observational Study.Journal of medical Internet research · 2026Observational
- A demethylation-driven gene signature predicts prognosis and therapeutic vulnerability in hepatocellular carcinoma.Scientific reports · 2026Article
- Symptom trajectory types during recovery from acute exacerbation of COPD and their association with systemic inflammatory burden and prognosis.Frontiers in cell and developmental biology · 2026Article
- A Noninvasive Predictive Model of Portal Hypertension in Patients with HCC Based on Clinical Features and Intra- and Peritumoral Pre-Fusion Radiomic Features.Journal of hepatocellular carcinoma · 2026Article
- Comparative Efficacy of Triple Versus Quadruple Therapy for the Eradication ofJGH open : an open access journal of gastroenterology and hepatology · 2025Review
- 15-Year Trends in Hepatocellular Carcinoma: Epidemiology, Treatment, and Outcomes from a Hospital-Based Registry.Gut and liver · 2025Article
- Associations of multimorbidity with mortality, hospital stay, and hospitalization costs in Chinese surgical patients: a retrospective cohort study.BMC anesthesiology · 2025Observational
- Dynamic nomogram for predicting long-term survival in patients with brain abscess.Chinese neurosurgical journal · 2025Article
- Classification of Parotid Tumors with Robust Radiomic Features from DCE- and DW-MRI.Journal of imaging · 2025Article
- Critique on "Investigating the Success Rate of Vaginal Delivery After Cesarean Section and Its Associated Factors in Afghan Women: Insights from a Maternity Hospital in Kabul" [Letter].International journal of women's health · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: We aimed to evaluate the generalizability of retrospective single-center cohort studies on prognosis of hepatocellular carcinoma (HCC) by comparing overall survival (OS) after various treatments between a nationwide multicenter cohort and a single-center cohort of HCC patients. Methods: Patients newly diagnosed with HCC between January 2008 and December 2018 were analyzed using data from the Korean Primary Liver Cancer Registry (multicenter cohort, n=16,443), and the Asan Medical Center HCC registry (single-center cohort, n=15,655). The primary outcome, OS after initial treatment, was compared between the two cohorts for both the entire population and for subcohorts with Child-Pugh A liver function (n=2797 and n=5151, respectively) treated according to the Barcelona-Clinic-Liver-Cancer (BCLC) strategy, using Log rank test and Cox proportional hazard models. Results: Patients of BCLC stages 0 and A (59.3% vs 35.2%) and patients who received curative treatment (42.1% vs 32.1%) were more frequently observed in the single-center cohort ( Conclusion: Comparisons of single-center and multicenter cohorts of HCC patients revealed significant differences in OS according to treatment modality after adjustment for prognostic variables. Therefore, the results of retrospective single-center cohort studies of HCC treatments may not be generalizable to real-world practice.
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