Evidence map›Paper›PMID 38973885›Full record

ArticleACS omega2024

First-Order Derivative Spectrophotometry for Simultaneous Determination of Vitamin C and Nicotinamide: Application in Quantitative Analysis of Cocrystals.

Clóvis A Balbinot Filho, Renata F Teixeira, Jônatas L Dias, Evertan A Rebelatto, Marcelo Lanza

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Clóvis A Balbinot FilhoDepartment of Chemical and Food Engineering, Federal University of Santa Catarina, UFSC, PO Box 476, 88040-900 Florianópolis, SC, Brazil.ORCID https://orcid.org/0000-0001-5667-4168
Renata F TeixeiraDepartment of Chemical and Food Engineering, Federal University of Santa Catarina, UFSC, PO Box 476, 88040-900 Florianópolis, SC, Brazil.
Jônatas L DiasDepartment of Chemical and Food Engineering, Federal University of Santa Catarina, UFSC, PO Box 476, 88040-900 Florianópolis, SC, Brazil.ORCID https://orcid.org/0000-0003-2096-0917
Evertan A RebelattoDepartment of Chemical and Food Engineering, Federal University of Santa Catarina, UFSC, PO Box 476, 88040-900 Florianópolis, SC, Brazil.
Marcelo LanzaDepartment of Chemical and Food Engineering, Federal University of Santa Catarina, UFSC, PO Box 476, 88040-900 Florianópolis, SC, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin C (l-ascorbic acid, ASC) and the amide form of vitamin B3 nicotinamide (NIC) can form cocrystals through hydrogen bonding. Currently, there is a lack of fast and reliable alternatives for precisely quantifying cocrystal components and their purity. Spectrophotometric analysis for quantifying such vitamin preparations is challenging due to overlapping absorbance bands in a narrow wavelength range in the ultraviolet (UV) region. Moreover, ASC undergoes progressive degradation if not diluted in a proper medium, requiring stability during quantitative analysis. This study adopted a fast, simple, and reliable two-component spectrophotometric assay for simultaneously determining ASC and NIC based on the first-order derivative spectrophotometry (FODS) method using sodium oxalate as a stabilizer for vitamin C. The FODS method showed linearity between 2 and 24 μg·mL

Identifiers

PMID38973885
PMCPMC11223235

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.