Evidence map›Paper›PMID 38973806›Full record

ArticleEthnicity & disease2024

Intracranial Volume Is Driven by Both Genetics and Early Life Exposures: The SOL-INCA-MRI Study.

Tamar Sofer, Einat Granot-Hershkovitz, Wassim Tarraf, Paola Filigrana, Carmen R Isasi, Shakira F Suglia, Robert Kaplan, Kent Taylor, Martha L Daviglus, Fernando D Testai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ethnicity & disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tamar SoferDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Einat Granot-HershkovitzDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Wassim TarrafInstitute of Gerontology, Wayne State University, Detroit, MI.
Paola FiligranaDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
Carmen R IsasiDepartment of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY.
Shakira F SugliaDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Robert KaplanDepartment of Epidemiology & Population Health, Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY.
Kent TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA.
Martha L DaviglusDepartment of Medicine, Institute for Minority Health Research, University of Illinois at Chicago, IL.
Fernando D TestaiDepartment of Neurology, University of Illinois at Chicago College of Medicine, Chicago, IL.
Donglin ZengDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Jianwen CaiDepartment of Biostatistics, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC.
Myriam FornageBrown Foundation Institute of Molecular Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX.
Hector M GonzálezDepartment of Neurosciences and Shiley-Marcos Alzheimer's Disease Center, University of California, San Diego, La Jolla, CA.
Charles DeCarliAlzheimer's Disease Research Center, Department of Neurology, University of California, Davis, Sacramento, CA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
UCSD Shiley-Marcos Alzheimer's Disease Research Center P30P30AG062429 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JAMES B BREWER · 2019 to 2026
$34.9M
UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's diseaseR01AG075758 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Charles DeCarli, Hector M Gonzalez · 2022 to 2026
$21.7M
MRI Measures of Cerebrovascular Injury and AD Atrophy in a Study of LatinosRF1AG054548 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2017 to 2017
$14.7M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Neurocognitive aging, MCI and Alzheimer's disease DNA methylation among diverse LatinosRF1AG061022 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FORNAGE, MYRIAM, GONZALEZ, HECTOR M · 2019 to 2019
$6.6M
Study of Latinos-Investigation of Neurocognitive Aging (SOL-INCA)R01AG048642 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GONZALEZ, HECTOR M · 2015 to 2019
$5.7M
Using polygenic risk scores and omics to study how suboptimal sleep accelerates cognitive aging in diverse populationsR01AG080598 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Tamar Sofer · 2023 to 2026
$3.6M
Thalassemia Clinical Research Network, CanadaU01HL065233 · NHLBI · UNIVERSITY HEALTH NETWORK · PI OLIVIERI, NANCY F · 2000 to 2009
$2.6M
Early and life course socioeconomic adversity and dementia risk in Hispanics/LatinosRF1AG077639 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DECARLI, CHARLES, GONZALEZ, HECTOR M · 2022 to 2023
$1.9M
GENETIC ARCHITECTURE OF PLASMA T-PA AND PAI-1R01HL065234 · NHLBI · VANDERBILT UNIVERSITY · PI MOORE, JASON H. · 2000 to 2004
$1.7M
NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NIA NIH HHS P30 AG062429NIA NIH HHS P30 AG072972NIA NIH HHS R01 AG048642NIA NIH HHS R01 AG075758NIA NIH HHS R01 AG080598NIA NIH HHS R21 AG056952NIA NIH HHS R21 AG070644NIA NIH HHS RF1 AG054548NIA NIH HHS RF1 AG061022NIA NIH HHS RF1 AG077639NIEHS NIH HHS P30 ES010126NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

Intracranial volume (ICV) reflects maximal brain development and is associated with later-life cognitive abilities. We quantified ICV among first- and second-generation Hispanic and Latino adults from the Study of Latinos-Investigation of Cognitive Aging - MRI (SOL-INCA-MRI), estimated ICV heritability, and tested its associations with previously reported genetic variants, both individually and as a genetic risk score (GRS). We also estimated the association of ICV with early life environmental measures: nativity or age of immigration and parental education. The estimated heritability of ICV was 19% (95% CI, 0.1%-56%) in n=1781 unrelated SOL-INCA-MRI individuals. Four of 10 tested genetic variants were associated with ICV and an increase of 1 SD of the ICV-GRS was associated with an increase of 10.37 cm

Indexed as

BrainHispanic or LatinoMagnetic Resonance ImagingAdolescentAdultAgedChildFemaleHumansMaleMiddle AgedOrgan SizeUnited StatesYoung AdultEarly Life DevelopmentGenetic AssociationsHeritabilityHispanic or Latino

Identifiers

PMID38973806
PMCPMC11223032

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.