Evidence map›Paper›PMID 38973730›Full record

ArticlePsychosomatic medicine2024

Lifetime Trauma Exposure and Arthritis in Older Adults.

Kristen Nishimi, Ruijia Chen, Gabriela Schmajuk, Thomas C Neylan, Aoife O'Donovan

Abstract read
In one paragraph

Article in Psychosomatic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kristen NishimiFrom the San Francisco Veterans Affairs Health Care System (Nishimi, Schmajuk, Neylan, O'Donovan); Department of Psychiatry and Behavioral Sciences, University of California San Francisco (Nishimi, Neylan, O'Donovan), San Francisco, California; Department of Epidemiology, Boston University School of Public Health (Chen), Boston, Massachusetts; and Departments of Medicine (Schmajuk) and Neurology (Neylan), University of California San Francisco, San Francisco, California.
Ruijia Chen
Gabriela Schmajuk
Thomas C Neylan
Aoife O'Donovan

Funding

Effects of inflammation on neural mechanisms of threat sensitivity in posttraumatic stress disorderK01MH109871 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'DONOVAN, AOIFE · 2016 to 2019
$737k
Lifecourse Stressors and Social Disparities in Cognitive Aging: The Roles of Social Networks and Sleep DisturbanceK00AG068431 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHEN, RUIJIA · 2021 to 2024
$330k
PTSD and Autoimmune Disease: Towards Causal Effects, Risk Factors, and MitigatorsIK2CX002627 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI Kristen Marie Nishimi · 2023 to 2027
–
CSRD VA IK2 CX002627NIA NIH HHS K00 AG068431NIMH NIH HHS K01 MH109871
6 · The paper itself

Abstract

objectiveExperiencing potentially traumatic events across one's lifecourse increases risk for poor physical health outcomes. Existing models emphasize the effects of any lifetime trauma exposure, risk accumulation (multiple traumas over time), and sensitive periods of exposure (specific exposure timepoints leading to lasting consequences). We examined how different indices of trauma exposure across the lifecourse were associated with later life arthritis, a common and debilitating health condition.

methodsData include 5717 Health and Retirement Study participants (age mean [standard deviation] = 65.4 [12.9] years) who reported on lifetime adversity and trauma in 2006-2008. Lifetime trauma exposure was modeled as any trauma, accumulation of traumas, and lifecourse profiles (no exposure, childhood only, adulthood only, childhood and adulthood exposure). Outcomes included prevalent arthritis at baseline and incident arthritis across 12 years of follow-up. Covariate-adjusted generalized linear models for prevalence ratios and Cox proportional hazards models for hazard ratios were conducted.

resultsAny lifetime trauma was associated with both prevalent arthritis at baseline (prevalence ratio = 1.13, 95% confidence interval = 1.05-1.22) and incident arthritis over 12 years (hazard ratio = 1.25, 95% confidence interval = 1.17-1.47). Greater trauma accumulation was significantly associated with both prevalent and incident arthritis. Childhood exposure was particularly strongly associated with prevalent and incident cases, with adulthood exposure being unassociated with incident arthritis. Across models, trauma exposure was associated with prevalent cases of both immune-related and osteoarthritis types.

conclusionsHigher lifetime trauma burden, especially during childhood, may predispose individuals to arthritis later in life. Early intervention or prevention efforts should identify trauma as an important risk factor for musculoskeletal health across the lifecourse.

Indexed as

ArthritisAgedAged, 80 and overFemaleHumansIncidenceLongitudinal StudiesMaleMiddle AgedPrevalencePsychological Trauma

Identifiers

PMID38973730
PMCPMC11444888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.