Evidence map›Paper›PMID 38973278›Full record

ArticleInternational journal of fertility & sterility2024

The Effects of Varicocelectomy on Sperm DNA Fragmentation and Conventional Semen Parameters in Men with Severe Oligoasthenoteratozoospermia: A Prospective Study.

Chaymae Rochdi, Ibtissam Bellajdel, Anouar El Moudane, Soufiane El Assri, Samira Mamri, Hafsa Taheri, Ali Barki, Ahmed Mimouni, Mohammed Choukri

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In one paragraph

Article in International journal of fertility & sterility, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chaymae RochdiMaternal-Child and Mental Health Research Laboratory, Faculty of Medicine and Pharmacy, First Mohammed University, Oujda, Morocco. Email: c.rochdi@ump.ac.ma.ORCID 0000-0002-4982-1614
Ibtissam BellajdelMedically Assisted Procreation Unit, Central Laboratory, Mohammed VI University Hospital Center, Oujda, Morocco.ORCID 0009-0005-1034-6034
Anouar El MoudaneUrology Service, University Hospital Center, Mohammed VI Oujda, Morocco.ORCID 0000-0002-5339-9348
Soufiane El AssriMaternal-Child and Mental Health Research Laboratory, Faculty of Medicine and Pharmacy, First Mohammed University, Oujda, Morocco.ORCID 0000-0002-3825-6736
Samira MamriMedically Assisted Procreation Unit, Central Laboratory, Mohammed VI University Hospital Center, Oujda, Morocco.ORCID 0000-0001-6149-0638
Hafsa TaheriMaternal-Child and Mental Health Research Laboratory, Faculty of Medicine and Pharmacy, First Mohammed University, Oujda, Morocco.ORCID 0000-0002-2355-8221
Ali BarkiUrology Service, University Hospital Center, Mohammed VI Oujda, Morocco.ORCID 0000-0002-0529-850X
Ahmed MimouniMaternal-Child and Mental Health Research Laboratory, Faculty of Medicine and Pharmacy, First Mohammed University, Oujda, Morocco.ORCID 0000-0001-5945-1015
Mohammed ChoukriMaternal-Child and Mental Health Research Laboratory, Faculty of Medicine and Pharmacy, First Mohammed University, Oujda, Morocco.ORCID 0000-0001-9275-5061

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe dilation and torsion of testicular veins in the plexus pampiniformis causes Varicocele, which is a surgically repairable cause of male infertility. This study assessed the impact of varicocelectomy on semen characteristics, total motile sperm count (TMSC) and sperm DNA integrity in patients with severe oligoasthenoteratozoospermia (OAT). MATERIALS AND

methodsIn this prospective study, semen samples of 360 men with severe OAT who underwent varicocelectomy according to World Health Organization (WHO) criteria 2021 were studied (pre-operatively and at 6, 12, and 18 months post-operatively).

resultsThe average age of our patients was 38.5 years. The mean spermatozoa concentration was found to be 1.60 ± 0.83 million/ml pre-operatively, while the mean post-operative concentration was 5.17 ± 1.23 million/ml at 6 months, 8.32 ± 0.98 million/ml at 12 months, and 13.51 ± 1.48 million/ml at 18 months (P<0.0001). The mean percentage of A+B motile spermatozoa was 2.92 ± 1.17% pre-operatively, 6.10 ± 1.51% at six months, 9.58 ± 1.49% at 12 months and 13.92 ± 1.88% at 18 months postoperatively (P<0.0001). The mean Modified David's morphology score was 3.80 ± 1.43% pre-operatively, 5.95 ± 1.23% at 6 months, 7.94 ± 1.18% at 12 months, and 10.82 ± 1.91% at 18 months post-operatively (P<0.0001). The mean of total motile sperm count (TMSC) was statistically improved after varicocelectomy (P<0.001). The mean of DNA fragmentation index (DFI) of the spermatozoa was 31.40 ± 0.52% pre-operatively, and post-operatively at 28.20 ± 0.32% at 6 months, 25.90 ± 0.31% at 12 months and 20.50 ± 0.40% at 18 months (P<0.001).

conclusionVaricocelectomy was associated with significant improvement of sperm parameters and DNA fragmentation resulting in significant improvement of spermatogenesis quality. We believe that universalization in the routinely used sperm dispersion chromatin (SDC) test could be beneficial in the treatment of infertility.

Indexed as

FragmentationMale Infertilitysevere OligoasthenoteratospermiaSpermatozoaVaricocele

Identifiers

PMID38973278
PMCPMC11245582

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.