SynthesisClinical and experimental dental research2024
Xenogeneic Collagen Matrix Versus Free Gingival Graft for Augmenting Peri-Implant Keratinized Mucosa Around Dental Implants: A Systematic Review and Meta-Analysis.
Synthesis in Clinical and experimental dental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Use of cells and/or biologics combined with scaffolds for soft tissue regeneration around dental implants.Journal of periodontology · 2026Pooled it
- Timing of keratinized mucosa augmentation and peri-implant outcomes: A systematic review and meta-analysis.Journal of prosthodontics : official journal of the American College of Prosthodontists · 2026Pooled it
- Pre-extractive Versus Postextractive Implant Site Preparation for Immediate Implant Placement in Mandibular Molar Sites: A Systematic Review and Meta-Analysis.International dental journal · 2026Pooled it
- Peri-Implantitis and Survival Outcomes of Tissue Level Versus Bone Level Dental Implants: A Systematic Review and Meta-Analysis.Clinical and experimental dental research · 2025Pooled it
- Comparative outcomes of xenogeneic collagen matrices and autogenous graft-based techniques to increase mucosal thickness and keratinised mucosa width at implant sites: are autologous grafts still the gold standard? A systematic review and meta-analysis of randomised clinical trials.Journal of periodontal & implant science · 2026Review
- Evaluation of soft tissue outcomes following keratinized tissue augmentation around dental implants using free gingival graft and xenogenic collagen matrix: A randomized clinical study.Bioinformation · 2026Article
- Soft-Tissue Volume Augmentation at Dental Implant Placement Using Collagen-Based Matrix Characterized by Oriented Open Pore Structure: A Retrospective Study with a Median Follow-Up of 17 Months.Bioengineering (Basel, Switzerland) · 2025Article
- Expert consensus on peri-implant keratinized mucosa augmentation at second-stage surgery.International journal of oral science · 2025Review
- Peri-Implant Soft-Tissue Augmentation Using Xenogeneic Collagen MatricesJournal of oral & maxillofacial researchReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesThere is a growing evidence to suggest augmenting peri-implant keratinized mucosa in the presence of ≤ 2 mm of keratinized mucosa. However, the most appropriate surgical technique and augmentation materials have yet to be defined. The aim of this systematic review and meta-analyses was to evaluate the clinical and patient-reported outcomes of augmenting keratinized mucosa around implants using free gingival graft (FGG) versus xenogeneic collagen matrix (XCM) before commencing prosthetic implant treatment. MATERIAL AND
methodsElectronic databases were searched to identify observational studies comparing implant sites augmented with FGG to those augmented with XCM. The risk of bias was assessed using the Cochrane Collaboration's Risk of Bias tool.
resultsSix studies with 174 participants were included in the present review. Of these, 87 participants had FGG, whereas the remaining participants had XCM. At 6 months, sites augmented with FGG were associated with less changes in the gained width of peri-implant keratinized mucosa compared to those augmented with XCM (mean difference 1.06; 95% confidence interval -0.01 to 2.13; p = 0.05). The difference, however, was marginally significant. The difference between the two groups in changes in thickness of peri-implant keratinized mucosa at 6 months was statistically significantly in favor of FGG. On the other hand, XCM had significantly shorter surgical time, lower postoperative pain score, and higher color match compared to FGG.
conclusionsWithin the limitation of this review, the augmentation of keratinized mucosa using FGG before the placement of the final prosthesis may have short-term positive effects on soft tissue thickness. XCM might be considered in aesthetically demanding implant sites and where patient comfort or shorter surgical time is a priority. The evidence support, however, is of low to moderate certainty; therefore, further studies are needed to support the findings of the present review.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.