ArticleAngewandte Chemie (International ed. in English)2024
Gold-Catalyzed Diyne-Ene Annulation for the Synthesis of Polysubstituted Benzenes through Formal [3+3] Approach with Amide as the Critical Co-Catalyst.
Article in Angewandte Chemie (International ed. in English), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Catalytic Generation of Cationic Gold Carbene Complexes From 7-Alkynylnorbornadienes and Their Intermolecular Cyclopropanation With Alkenes.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Recent Advances in Benzannulation Approaches to Aromatic Frameworks.Chemistry, an Asian journal · 2026Review
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8 authors.
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Abstract
The one-step synthesis of tetra-substituted benzenes was accomplished via gold-catalyzed diyne-ene annulation. Distinguished from prior modification methods, this novel strategy undergoes formal [3+3] cyclization, producing polysubstituted benzenes with exceptional efficiency. The critical factor enabling this transformation was the introduction of amides, which were reported for the first time in gold catalysis as covalent nucleophilic co-catalysts. This interesting protocol not only offers a new strategy to achieve functional benzenes with high efficiency, but also enlightens potential new reaction pathways within gold-catalyzed alkyne activation processes.
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