Evidence map›Paper›PMID 38972996›Full record

ArticleGut pathogens2024

Power-law scaling in intratumoral microbiota of colorectal cancer.

Nikolas Dovrolis, Maria Gazouli, François Rigal, Robert J Whittaker, Thomas J Matthews, Konstantinos Georgiou, George Theodoropoulos, Kostas A Triantis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut pathogens, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Gut Microbiota and Colorectal Cancer: A Balance Between Risk and Protection.International journal of molecular sciences · 2025
    Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nikolas DovrolisDepartment of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece. ndovroli@med.uoa.gr.
Maria GazouliDepartment of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, 11527, Greece. mgazouli@med.uoa.gr.
François RigalInstitut Des Sciences Analytiques et de Physico Chimie pour L'environnement et les Materiaux, CNRS - Université de Pau et des Pays de l'Adour - E2S UPPA, UMR5254, Pau, 64000, France.
Robert J WhittakerSchool of Geography and the Environment, University of Oxford, Oxford, UK.
Thomas J MatthewsCE3C - Centre for Ecology, Evolution and Environmental Changes/Azorean Biodiversity Group, Faculty of Agricultural Sciences and Environment, CHANGE - Global Change and Sustainability Institute and Universidade dos Açores, Angra do Heroísmo, Açores, PT-9700-042, Portugal.
Konstantinos Georgiou1st Department of Propaedeutic Surgery, Medical School, National Kapodistrian University of Athens, Hippocratio Hospital, Athens, 11527, Greece.
George Theodoropoulos1st Department of Propaedeutic Surgery, Medical School, National Kapodistrian University of Athens, Hippocratio Hospital, Athens, 11527, Greece.
Kostas A TriantisDepartment of Ecology and Taxonomy, National & Kapodistrian University of Athens, Athens, 11527, Greece. ktriantis@biol.uoa.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has recently been proposed that the study of microbial dynamics in humans may gain insights from island biogeographical theory. Here, we test whether the diversity of the intratumoral microbiota of colorectal cancer tumors (CRC) follows a power law with tumor size akin to the island species-area relationship. We confirm a direct correlation between the quantity of Amplicon Sequence Variants (ASVs) within CRC tumors and tumor sizes, following a (log)power model, explaining 47% of the variation. Understanding the processes involved, potentially through the analogy of tumors and islands, may ultimately contribute to future clinical and therapeutic strategies.

Indexed as

CancerIntratumoral microbiomeIsland species–area relationship

Identifiers

PMID38972996
PMCPMC11229225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.