Evidence map›Paper›PMID 38972979›Full record

ArticleWorld journal of surgery2025

Long-term oncological outcomes of follicular thyroid cancer in adolescents and young adults: A nationwide population-based study.

Daniël J van de Berg, Christiaan F Mooij, A S Paul van Trotsenburg, Hanneke M van Santen, Sheila C E J Terwisscha van Scheltinga, Menno R Vriens, Schelto Kruijff, Els J M Nieveen van Dijkum, Anton F Engelsman, Joep P M Derikx

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Article in World journal of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Daniël J van de BergDepartment of Pediatric Surgery, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-3670-7422
Christiaan F MooijDepartment of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
A S Paul van TrotsenburgDepartment of Pediatric Endocrinology, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Hanneke M van SantenDepartment of Pediatric Endocrinology, Wilhelmina Children's Hospital, Utrecht University Medical Center, University of Utrecht, Utrecht, The Netherlands.
Sheila C E J Terwisscha van ScheltingaDepartment of Pediatric Surgical Oncology, Princess Máxima Center, Utrecht University Medical Center, University of Utrecht, Utrecht, The Netherlands.
Menno R VriensDepartment of Surgery, University Medical Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
Schelto KruijffDepartment of Surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Els J M Nieveen van DijkumDepartment of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Anton F EngelsmanDepartment of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Joep P M DerikxDepartment of Pediatric Surgery, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

Funding

KiKa Project 441
6 · The paper itself

Abstract

backgroundFollicular thyroid carcinoma (FTC) in adolescents and young adults (AYAs) is rare and data on long-term oncological outcomes are scarce. This study aimed to describe the long-term recurrence and survival rates of AYAs with FTC, and identify risk factors for recurrence.

methodsThis is a retrospective cohort study combining two national databases, including all patients aged 15-39 years, diagnosed with FTC in The Netherlands between 2000 and 2016. Age, sex, tumor size, focality, positive margins, angioinvasion, pT-stage, and pN-stage were included in a Cox proportional hazard model to identify risk factors for recurrence.

resultsWe included 192 patients. Median age was 31.0 years (IQR 24.7-36.3) and the male to female ratio was 1:4.1. Most patients presented with a minimally invasive FTC (MI-FTC) (95%). Five patients presented with synchronous metastases (2.6%), including two with locoregional metastases (1%) and three with distant metastases (1.6%). During a median follow-up of 12.0 years, three patients developed a recurrence (1.6%), of which one patient developed a local recurrence (33%), and two patients a distant recurrence (67%). Five patients died during follow-up (2.6%). Cause of death was not captured. A Cox proportional hazard model could not be performed due to the low number of recurrences.

conclusionsFTC in AYAs is generally characterized as a low-risk tumor, as it exhibits a very low recurrence rate, a high overall survival, and it typically presents as MI-FTC without synchronous metastases. These findings underscore the favorable long-term oncological prognosis of FTC in AYAs.

Indexed as

Adenocarcinoma, FollicularNeoplasm Recurrence, LocalThyroid NeoplasmsAdolescentAdultFemaleFollow-Up StudiesHumansMaleNeoplasm StagingNetherlandsRetrospective StudiesRisk FactorsSurvival RateThyroidectomyYoung Adultadolescents and young adultsAYAsfollicular thyroid cancerlong‐term oncological outcomesrecurrencesurvival

Identifiers

PMID38972979
PMCPMC11711111

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