Survey on Interaction Between Nutrient Status and Selected Polymorphisms in Association with Weight Loss of Patients with Severe Obesity Underwent Bariatric Surgery.

Sara Cheraghi, Golmehr Taheri, Saeed Safari, Hooman Bakhshandeh, Mojtaba Malek, Bahar Moghimian, Azadeh Mottaghi

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Article in Obesity surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Sara CheraghiEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Golmehr TaheriDepartment of Endocrinology and Metabolism, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Saeed SafariFiroozgar General Hospital, Iran University of Medical Sciences, Tehran, Iran.

Hooman BakhshandehHeart Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.

Mojtaba MalekResearch Center for Prevention of Cardiovascular Diseases, Institute of Endocrinology Metabolism, Iran University of Medical Sciences, Endocrinology & Metabolism, Tehran, Iran.

Bahar MoghimianEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Azadeh MottaghiEndocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran. mottaghi.a@iums.ac.ir.ORCID 0000-0002-1325-8946

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is little information about the effect of single nucleotide polymorphisms (SNP) and nutritional status and weight loss after bariatric surgery. This study investigated the interactive effect of eight obesity-related SNPs and nutritional status on weight loss after Roux-en-Y gastric bypass (RYGB).

methodThis is a case-control study. After 1-year follow-up, the patients who underwent RYGB were dividing into two groups. The case group consisted of patients who lost more than 50% of their excess body weight (EBW%) 1 year after the surgery. The control group included patients who lost < 50% of EBW at same time frame. Then, the relationship between eight SNPs related to UCP2, FTO, LEPR, GHRL, and NPY genes with weight loss were checked.

resultsIn this study, 160 patients were recruited. The median of age for case and control group were 43 and 42 respectively. The presence of mutant variant NPYrs16147 had a significant relationship in terms of weight loss between the two groups (P > 0.05). In dominant model, two SNPs, UCP2 rs659366 and UCP2 rs660339, showed protective effect of the vitamin D deficiency.

conclusionIn conclusion, the presence mutant variant of NPYrs16147 is directly related to the incidence of weight loss greater than 50% of EBW. However, it is apparent individual behavioral, dietary, and other factors may have more influence on weight loss among patients underwent RYGB.

Indexed as

Gastric BypassNutritional StatusObesity, MorbidPolymorphism, Single NucleotideUncoupling Protein 2Weight LossAdultCase-Control StudiesFemaleHumansMaleMiddle AgedUCP2 protein, humanUncoupling Protein 2Bariatric surgeryObesitySingle nucleotide polymorphismWeight loss

Identifiers

PMID38972938

DOI10.1007/s11695-024-07305-2

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.