ArticleJournal of molecular modeling2024
Bionanosensor utilizing single-layer graphene for the detection of iridovirus.
Article in Journal of molecular modeling, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- FEM simulation of SARS-CoV-2 sensing in single-layer graphene-based bionanosensors.Journal of molecular modeling · 2024Article
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2 authors.
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Abstract
contextIridoviruses, a group of double-stranded DNA viruses, pose a significant threat to various aquatic animals, causing substantial economic losses in aquaculture and impacting ecosystem health. Early and accurate detection of these viruses is crucial for effective disease management and control. Conventional diagnostic methods, including polymerase chain reaction (PCR) and virus isolation, often require specialized laboratories, skilled personnel, and considerable time. This highlights the need for rapid, sensitive, and cost-effective diagnostic tools for iridovirus detection. Single-layer graphene, a two-dimensional material with unique properties like high surface area, excellent electrical conductivity, and chemical stability, has emerged as a versatile platform for biosensing applications. This paper explores the potential of employing single-layer graphene in the development of a bionanosensor for the sensitive and rapid detection of iridoviruses. The aim of the present investigation is to develop a sensor by analyzing the vibrational responses of single-layer graphene sheets (SLGS) with attached microorganisms. Graphene-based virus sensors typically rely on the interaction between the virus and the graphene surface, which lead to changes in the frequency response of graphene. This change is measured and used to detect the presence of the virus. Its high surface-to-volume ratio and sensitivity to changes in its frequency make it a highly sensitive platform for virus detection.
methodsWe employ finite element method (FEM) analysis to model the sensor's performance and optimize its design parameters. The simulation results highlight the sensor's potential for achieving high sensitivity and rapid detection of iridovirus. Bridged and simply supported with roller support boundary conditions applied at the ends of SLG structure. Simulations have been performed to see how SLG behaves when used as sensors. A single-layer graphene armchair SLG (5,5) with 50-nm length exhibits its highest frequency vibration at 8.66 × 10
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