Evidence map›Paper›PMID 38972779›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2024

Reversal of cognitive deficits in FUS

Mari Carmen Pelaez, Frédéric Fiore, Nancy Larochelle, Afrooz Dabbaghizadeh, Mario Fernández Comaduran, Danielle Arbour, Sandra Minotti, Laetitia Marcadet, Martine Semaan, Richard Robitaille and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mari Carmen PelaezDepartment of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, QC Canada. Electronic address: maria-del-carmen.pelaez-brenes.1@ulaval.ca.
Frédéric FioreDépartement de Neurosciences and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, and Centre Interdisciplinaire de Recherche sur le Cerveau et l'apprentissage, Montréal, QC Canada. Electronic address: frederic.fiore@uni-heidelberg.de.
Nancy LarochelleDepartment of Neurology & Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, QC Canada. Electronic address: nancy.larochelle@mcgill.ca.
Afrooz DabbaghizadehDepartment of Neurology & Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, QC Canada. Electronic address: Afrooz.dabbaghi@gmail.com.
Mario Fernández ComaduranDepartment of Neurology & Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, QC Canada. Electronic address: mario.fernandez@mcgill.ca.
Danielle ArbourDépartement de Neurosciences and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, and Centre Interdisciplinaire de Recherche sur le Cerveau et l'apprentissage, Montréal, QC Canada. Electronic address: danielle.arbour@umontreal.ca.
Sandra MinottiDepartment of Neurology & Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, QC Canada. Electronic address: sandra.minotti@mcgill.ca.
Laetitia MarcadetDepartment of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, QC Canada. Electronic address: laetitia.marcadet.1@ulaval.ca.
Martine SemaanDépartement de Neurosciences and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, and Centre Interdisciplinaire de Recherche sur le Cerveau et l'apprentissage, Montréal, QC Canada. Electronic address: martine.semaan@umontreal.ca.
Richard RobitailleDépartement de Neurosciences and Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, and Centre Interdisciplinaire de Recherche sur le Cerveau et l'apprentissage, Montréal, QC Canada. Electronic address: richard.robitaille@umontreal.ca.
Josephine N NalbantogluDepartment of Neurology & Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, QC Canada. Electronic address: josephine.nalbantoglu@mcgill.ca.
Chantelle F SephtonDepartment of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, QC Canada. Electronic address: chantelle.sephton.1@ulaval.ca.
Heather D DurhamDepartment of Neurology & Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, QC Canada. Electronic address: heather.durham@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein misfolding and mislocalization are common to both familial and sporadic forms of amyotrophic lateral sclerosis (ALS). Maintaining proteostasis through induction of heat shock proteins (HSP) to increase chaperoning capacity is a rational therapeutic strategy in the treatment of ALS. However, the threshold for upregulating stress-inducible HSPs remains high in neurons, presenting a therapeutic obstacle. This study used mouse models expressing the ALS variants FUS

Indexed as

Amyotrophic Lateral SclerosisHistone Deacetylase InhibitorsMice, TransgenicAnimalsCognitive DysfunctionDisease Models, AnimalHeat-Shock ProteinsHumansHydroxylaminesMiceMice, Inbred C57BLSpinal CordarimoclomolHeat-Shock ProteinsHistone Deacetylase InhibitorsHydroxylaminesAmyotrophic lateral sclerosisArimoclomolFrontotemporal dementiaFUSHeat shock proteinsHistone deacetylase inhibitor

Identifiers

PMID38972779
PMCPMC11579874

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.