Evidence map›Paper›PMID 38971920›Full record

ArticleJournal of cardiovascular translational research2024

High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation.

Yonghui Xie, Taoyue Yao, Xiaogang Zhu, Fan Yang, Haoqin Fan, Shirui Cao, Huaiyang Chen, Manzhen Liao, Yuanxi Xia, Jinqiao Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yonghui Xie *Academy of Pediatrics, University of South China, Changsha, 410007, China.
Taoyue Yao *Department of Ultrasound, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, 410007, China.
Xiaogang ZhuDepartment of Obstetrics and Gynecology, Third Xiangya Hospital, Central South University, Changsha, 410013, China.
Fan YangDepartment of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Haoqin FanAcademy of Pediatrics, University of South China, Changsha, 410007, China.
Shirui CaoClass 2115, Changsha Yali High School, Changsha, 410007, China.
Huaiyang ChenAcademy of Pediatrics, University of South China, Changsha, 410007, China.
Manzhen LiaoAcademy of Pediatrics, University of South China, Changsha, 410007, China.
Yuanxi XiaDepartment of Anesthesiology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, 410007, China.
Jinqiao LiuDepartment of Ultrasound, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, 410007, China.
Zhenghui XiaoDepartment of Pediatric Intensive Care, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, 410007, China.
Zhou YangDepartment of Cardiology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, 410007, China. 153673747@qq.com.
Yunbin XiaoDepartment of Cardiology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital), Changsha, 410007, China. xiaoyunbinrui@126.com.ORCID 0000-0003-3888-0069

Funding

Department of Science and Technology of Hunan Province 2021SK50503Health Commission of Hunan Province 20200587Health Commission of Hunan Province 20200596Hunan Clinical Research Center for Children's Cardiovascular Diseases 2021SK4019
6 · The paper itself

Abstract

This research aimed to explore whether high-intensity focused ultrasound (HIFU) could conduct pulmonary artery denervation (PADN). HIFU was performed in pulmonary arteries of 6 normotensive rabbits at dose of 250W, 6 times for each rabbit, and an additional 6 rabbits served as controls. Then ATEPH was induced in both groups by intravenous infusion of autogeneic thrombus. Hemodynamics and ultrasonography parameters were measured by right heart catheter and echocardiography pre- and post-establishment of ATEPH models in both groups. Histological analysis and immunohistochemistry of tyrosine hydroxylase (TH) were also performed. After PADN procedures, 5 rabbits were successfully conducted PADN, of which ablation zone was also observed in right auricle or right lung in 4 rabbits. Ablation zone was detected only in right lung in 1 rabbit. Compared with control group, milder right heart hemodynamic changes were found in PADN group, accompanied by improved ultrasound parameters in PADN group. HIFU can acutly damage SNs around pulmonary artery successfully, which may be a new choice to conduct PADN. However, the accuracy of HIFU with PADN needs to be improved.

Indexed as

Disease Models, AnimalHemodynamicsHigh-Intensity Focused Ultrasound AblationPulmonary ArteryAnimalsMaleRabbitsSympathectomyTyrosine 3-MonooxygenaseTyrosine 3-MonooxygenaseHigh-intensity Focused UltrasoundPulmonary Arterial HypertensionPulmonary Artery DenervationSympathetic Nerves

Identifiers

PMID38971920
PMCPMC11635049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.