Evidence map›Paper›PMID 38971919›Full record

ArticlePharmacological reports : PR2024

Uncovering the unique characteristics of different groups of 5-HT

Szymon K Kordylewski, Ryszard Bugno, Andrzej J Bojarski, Sabina Podlewska

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmacological reports : PR, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Szymon K KordylewskiMaj Institute of Pharmacology Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.ORCID http://orcid.org/0000-0003-1147-4837
Ryszard BugnoMaj Institute of Pharmacology Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.ORCID http://orcid.org/0000-0003-3741-674X
Andrzej J BojarskiMaj Institute of Pharmacology Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland.ORCID http://orcid.org/0000-0003-1417-6333
Sabina PodlewskaMaj Institute of Pharmacology Polish Academy of Sciences, Smętna 12, 31-343, Kraków, Poland. smusz@if-pan.krakow.pl.ORCID http://orcid.org/0000-0002-2891-5603

Funding

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk Statutory funds of the Department of Medicinal Chemistry
6 · The paper itself

Abstract

backgroundThe serotonin 5-HT

methodsIn response to the need for identification of molecular determinants for 5-HT

resultsThe obtained comprehensive set of 2160 compounds was divided into dozens of subsets, and a pharmacophore model was developed for each group. The results from the docking and molecular dynamics simulations have enabled the identification of crucial ligand-protein interactions that are essential for the compound's activity towards 5-HT

conclusionsThe findings from the molecular modeling study provide valuable insights that can guide medicinal chemists in the development of new 5-HT

Indexed as

Receptors, SerotoninAnimalsHumansLigandsMolecular Docking SimulationMolecular Dynamics SimulationProtein BindingLigandsReceptors, Serotoninserotonin 5 receptor5-HT5ARDockingLigand databaseMolecular dynamicsPharmacophore modelingSerotonin receptors

Identifiers

PMID38971919
PMCPMC11387456

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.