ArticleNature communications2024
The loci of environmental adaptation in a model eukaryote.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- The shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations.Nature ecology & evolution · 2026Article
- Toward a Functional Genetics of Adaptation: Insights From Microbial Experimental Evolution.Genome biology and evolution · 2026Review
- Spontaneous mutation rate and spectrum are modulated by organismal fitness.Science advances · 2026Article
- ERG phase separation attenuates cellular senescence.iScience · 2026Article
- Repeatability of gene expression evolution in experimental environmental adaptation.Nature communications · 2026Article
- Adaptive tracking with antagonistic pleiotropy results in seemingly neutral molecular evolution.Nature ecology & evolution · 2025Article
- Functional synonymous mutations and their evolutionary consequences.Nature reviews. Genetics · 2025Review
- Resource presentation dictates genetic and phenotypic adaptation in yeast.BMC ecology and evolution · 2025Article
- Functional Divergence of Plant-Derived Thaumatin-Like Protein Genes in Two Closely Related Whitefly Species.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Spontaneous and environment induced genomic alterations in yeast model.Cell insight · 2025Review
- Comparative adaptability of 307Frontiers in microbiology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
While the underlying genetic changes have been uncovered in some cases of adaptive evolution, the lack of a systematic study prevents a general understanding of the genomic basis of adaptation. For example, it is unclear whether protein-coding or noncoding mutations are more important to adaptive evolution and whether adaptations to different environments are brought by genetic changes distributed in diverse genes and biological processes or concentrated in a core set. We here perform laboratory evolution of 3360 Saccharomyces cerevisiae populations in 252 environments of varying levels of stress. We find the yeast adaptations to be primarily fueled by large-effect coding mutations overrepresented in a relatively small gene set, despite prevalent antagonistic pleiotropy across environments. Populations generally adapt faster in more stressful environments, partly because of greater benefits of the same mutations in more stressful environments. These and other findings from this model eukaryote help unravel the genomic principles of environmental adaptation.
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