Evidence map›Paper›PMID 38971718›Full record

ArticleBMC microbiology2024

Comparative genomics of quinolone-resistant Escherichia coli from broilers and humans in Norway.

Jannice Schau Slettemeås, Camilla Sekse, Marianne Sunde, Madelaine Norström, Astrid Louise Wester, Umaer Naseer, Gunnar Skov Simonsen, Charlotte Rosenberg Ulstad, Anne Margrete Urdahl, Karin Lagesen

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jannice Schau SlettemeåsNorwegian Veterinary Institute, P.O. box 64, Ås, 1431, Norway. jannice.schau-slettemeas@vetinst.no.
Camilla SekseNorwegian Veterinary Institute, P.O. box 64, Ås, 1431, Norway.
Marianne SundeNorwegian Veterinary Institute, P.O. box 64, Ås, 1431, Norway.
Madelaine NorströmNorwegian Veterinary Institute, P.O. box 64, Ås, 1431, Norway.
Astrid Louise WesterNorwegian Institute of Public Health, P.O. box 4404, Nydalen, Oslo, 0403, Norway.
Umaer NaseerNorwegian Institute of Public Health, P.O. box 4404, Nydalen, Oslo, 0403, Norway.
Gunnar Skov SimonsenUniversity Hospital of North Norway, Breivika, Tromsø, 9038, Norway.
Charlotte Rosenberg UlstadNorwegian Institute of Public Health, P.O. box 4404, Nydalen, Oslo, 0403, Norway.
Anne Margrete UrdahlNorwegian Veterinary Institute, P.O. box 64, Ås, 1431, Norway.
Karin LagesenNorwegian Veterinary Institute, P.O. box 64, Ås, 1431, Norway.

Funding

Norwegian Research Funding for Agriculture and Food Industry 244140
6 · The paper itself

Abstract

backgroundThe usage of fluoroquinolones in Norwegian livestock production is very low, including in broiler production. Historically, quinolone-resistant Escherichia coli (QREC) isolated from Norwegian production animals rarely occur. However, with the introduction of a selective screening method for QREC in the Norwegian monitoring programme for antimicrobial resistance in the veterinary sector in 2014; 89.5% of broiler caecal samples and 70.7% of broiler meat samples were positive. This triggered the concern if there could be possible links between broiler and human reservoirs of QREC. We are addressing this by characterizing genomes of QREC from humans (healthy carriers and patients) and broiler isolates (meat and caecum).

resultsThe most frequent mechanism for quinolone resistance in both broiler and human E. coli isolates were mutations in the chromosomally located gyrA and parC genes, although plasmid mediated quinolone resistance (PMQR) was also identified. There was some relatedness of the isolates within human and broiler groups, but little between these two groups. Further, some overlap was seen for isolates with the same sequence type isolated from broiler and humans, but overall, the SNP distance was high.

conclusionBased on data from this study, QREC from broiler makes a limited contribution to the incidence of QREC in humans in Norway.

Indexed as

Anti-Bacterial AgentsChickensDrug Resistance, BacterialEscherichia coliEscherichia coli InfectionsQuinolonesAnimalsCecumDNA GyraseDNA Topoisomerase IVEscherichia coli ProteinsGenome, BacterialGenomicsHumansMeatMicrobial Sensitivity TestsAnti-Bacterial AgentsDNA GyraseDNA Topoisomerase IVEscherichia coli ProteinsQuinolonesAntimicrobial resistanceBroilerCore genome phylogenyEscherichia coliHumanQuinolone resistance

Identifiers

PMID38971718
PMCPMC11227169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.