Evidence map›Paper›PMID 38971479›Full record

ArticleNeurobiology of disease2024

Altered ventilatory responses to hypercapnia-hypoxia challenges in a preclinical SUDEP model involve orexin neurons.

Shruthi H Iyer, Jillian E Hinman, Ted Warren, Stephanie A Matthews, Timothy A Simeone, Kristina A Simeone

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Sudden Unexpected Death in Epilepsy: Central Respiratory Chemoreception.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shruthi H IyerDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Jillian E HinmanDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Ted WarrenDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Stephanie A MatthewsDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Timothy A SimeoneDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA.
Kristina A SimeoneDepartment of Pharmacology and Neuroscience, Creighton University School of Medicine, Omaha, NE 68178, USA. Electronic address: kristinasimeone@creighton.edu.

Funding

Autoresuscitation and SUDEPR01NS126418 · NINDS · CREIGHTON UNIVERSITY · PI Kristina A Simeone, Timothy A. Simeone · 2022 to 2026
$1.7M
Adenosine, Hypocretin and Sleep Disorder Comorbidities Associated with EpilepsyR01NS072179 · NINDS · CREIGHTON UNIVERSITY · PI SIMEONE, KRISTINA A · 2012 to 2016
$1.5M
Replacing an Animal Resource Facility Cage Washer.G20RR024001 · NCRR · CREIGHTON UNIVERSITY · PI DRESCHER, KRISTEN · 2007 to 2007
$638k
Mechanisms of SUDEP: Failure to AutoresuscitateR21NS111389 · NINDS · CREIGHTON UNIVERSITY · PI SIMEONE, KRISTINA A · 2020 to 2020
$400k
NCRR NIH HHS G20 RR024001NINDS NIH HHS R01 NS072179NINDS NIH HHS R01 NS126418NINDS NIH HHS R21 NS111389
6 · The paper itself

Abstract

Failure to recover from repeated hypercapnia and hypoxemia (HH) challenges caused by severe GCS and postictal apneas may contribute to sudden unexpected death in epilepsy (SUDEP). Our previous studies found orexinergic dysfunction contributes to respiratory abnormalities in a preclinical model of SUDEP, Kcna1

Indexed as

Disease Models, AnimalHypercapniaHypoxiaMice, KnockoutNeuronsOrexinsSudden Unexpected Death in EpilepsyAnimalsKv1.1 Potassium ChannelMaleMiceMice, Inbred C57BLKcna1 protein, mouseKv1.1 Potassium ChannelOrexinsAcidosisChemosensingDORADual orexin receptor antagonistElectrophysiologyEpilepsyHypercapniaHypocretinHypoxiaKcna-null miceKv1.1OrexinRespirationRespiratory dysfunctionSeizuresSudden unexpected death in epilepsySUDEP

Identifiers

PMID38971479
PMCPMC11648317

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.