Evidence map›Paper›PMID 38971398›Full record

ReviewDevelopmental biology2024

Overview of chromatin regulatory processes during surface ectodermal development and homeostasis.

Meagan C Branch, Madison Weber, Meng-Yen Li, Pooja Flora, Elena Ezhkova

Abstract readReview
In one paragraph

Review in Developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Meagan C BranchBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Madison WeberBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Meng-Yen LiBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pooja FloraBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: pooja.flora@mssm.edu.
Elena EzhkovaBlack Family Stem Cell Institute, Department of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: elena.ezhkova@mssm.edu.

Funding

Skin Biology and Diseases Resource-based Center at Mount SinaiP30AR079200 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Elena Ezhkova · 2021 to 2026
$5.2M
Toward Understanding the Role of the Polycomb Complex in Skin ControlR01AR069078 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EZHKOVA, ELENA · 2016 to 2024
$4.4M
Toward understanding the molecular mechanisms of Merkel cell fate determinationR01AR063724 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI EZHKOVA, ELENA · 2012 to 2021
$4.2M
Identifying epigenetic factors in control of epidermal stem cell longevity in the adult skinK99AR082956 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FLORA, POOJA · 2023 to 2024
$212k
The Epigenetic Regulation of Epidermal Stem Cells in Adult Skin Wound HealingF31AR082689 · NIAMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Meagan Branch · 2024 to 2026
$119k
Merkel cell polyomavirus T-Antigen mediated reprogramming in adult epidermisF31CA280993 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WEBER, MADISON · 2024 to 2025
$81k
NCI NIH HHS F31 CA280993NIAMS NIH HHS F31 AR082689NIAMS NIH HHS K99 AR082956NIAMS NIH HHS P30 AR079200NIAMS NIH HHS R01 AR063724NIAMS NIH HHS R01 AR069078
6 · The paper itself

Abstract

The ectoderm is the outermost of the three germ layers of the early embryo that arise during gastrulation. Once the germ layers are established, the complex interplay of cellular proliferation, differentiation, and migration results in organogenesis. The ectoderm is the progenitor of both the surface ectoderm and the neural ectoderm. Notably, the surface ectoderm develops into the epidermis and its associated appendages, nails, external exocrine glands, olfactory epithelium, and the anterior pituitary. Specification, development, and homeostasis of these organs demand a tightly orchestrated gene expression program that is often dictated by epigenetic regulation. In this review, we discuss the recent discoveries that have highlighted the importance of chromatin regulatory mechanisms mediated by transcription factors, histone and DNA modifications that aid in the development of surface ectodermal organs and maintain their homeostasis post-development.

Indexed as

ChromatinEctodermGene Expression Regulation, DevelopmentalHomeostasisAnimalsCell DifferentiationEpigenesis, GeneticHistonesHumansTranscription FactorsChromatinHistonesTranscription FactorsChromatin regulationDevelopmentEpigeneticsHomeostasisSurface ectoderm

Identifiers

PMID38971398
PMCPMC11317222

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.