ArticleJournal of cardiac failure2025
Long-term Changes in Body Composition and Exercise Capacity Following Calorie Restriction and Exercise Training in Older Patients with Obesity and Heart Failure With Preserved Ejection Fraction.
Article in Journal of cardiac failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Cardiometabolic Heart Failure with Preserved Ejection Fraction (HFpEF): Epidemiology, Mechanisms, and the Role of Lifestyle Modification.Journal of cardiovascular development and disease · 2026Review
- Glucagon-like Peptide-1 Therapy in Obesity-Related Heart Failure with Preserved Ejection Fraction: Mechanisms, Clinical Evidence, and Implications.Journal of clinical medicine · 2026Review
- Modifying the structural substrate and progression of heart failure with preserved ejection fraction using a regular exercise regimen in pigs.American journal of physiology. Heart and circulatory physiology · 2026Article
- Sedentary lifestyle is independently associated with higher fat mass index regardless of physical activity level in patients with coronary artery disease.BMC cardiovascular disorders · 2025Article
- Central Adiposity or Hypertension: Which Drives Heart Failure With a Preserved Ejection Fraction?Journal of the American College of Cardiology · 2025Review
- Body composition in patients with obesity-related heart failure with preserved ejection fraction: A comparison study.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- The impact of lifestyle-based weight loss in older adults with obesity on muscle and bone health: a balancing act.Obesity (Silver Spring, Md.) · 2025Review
- Aerobic, resistance, and specialized exercise training in heart failure with preserved ejection fraction: A state-of-the-art review.Heart failure reviews · 2025Review
- Insights Into the Role of Obesity in Heart Failure With Preserved Ejection Fraction: Pathophysiology and Management.The Canadian journal of cardiology · 2025Review
- Dietary Interventions in Heart Failure With Preserved Ejection Fraction: A Scoping Review.JACC. Advances · 2025Review
- An interdisciplinary approach to ensure adherence to exercise and potentially reduce adverse cardiac events in cancer patients: primers in cardio-oncology.Frontiers in oncology · 2025Article
- Assessing Static Balance, Balance Confidence, and Fall Rate in Patients with Heart Failure and Preserved Ejection Fraction: A Comprehensive Analysis.Sensors (Basel, Switzerland) · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundObesity combined with heart failure with preserved ejection fraction (HFpEF) is the dominant form of HF among older persons. In a randomized trial, we previously showed that a 5-month calorie restriction (CR) program, with or without aerobic exercise training (AT), resulted in significant weight and fat loss and improved exercise capacity. However, little is known regarding the long-term effects of these outcomes after a short-term (5-month) intervention of CR with or without AT in older patients with obesity and HFpEF.
methodsSixteen participants from either the CR or CR+AT who experienced significant weight loss ≥ 2 kg were reexamined after a long-term follow-up endpoint (28.0 ± 10.8 months) without intervention. The follow-up assessment included body weight and composition via dual-energy X-ray absorptiometry and exhaustive cardiopulmonary treadmill exercise testing.
resultsCompared to the 5-month time-point intervention endpoint, at the long-term follow-up endpoint, mean body weight increased +5.2 ± 4.0 kg (90.7 ± 11.2 kg vs 95.9 ± 11.9; P < 0.001) due to increased fat mass (38.9 ± 9.3 vs 43.8 ± 9.8; P < 0.001) with no change in lean mass (49.6 ± 7.1 vs 49.9±7.6; P = 0.67), resulting in worse body composition (decreased lean-to-fat mass). Change in total mass was strongly and significantly correlated with change in fat mass (r = 0.75; P < 0.001), whereas there appeared to be a weaker correlation with change in lean mass (r = 0.50; P = 0.051). Additionally, from the end of the 5-month time-point intervention endpoint to the long-term follow-up endpoint, there were large, significant decreases in VO
conclusionAlthough CR and CR+AT in older patients with obesity and HFpEF can improve body composition and exercise capacity significantly, these positive changes diminish considerably during long-term follow-up endpoints, and regained weight is predominantly adipose, resulting in worsened overall body composition compared to baseline. This suggests a need for long-term adherence strategies to prevent weight regain and maintain improvements in body composition and exercise capacity following CR in older patients with obesity and HFpEF.
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