Evidence map›Paper›PMID 38971217›Full record

ArticleJournal of molecular and cellular cardiology2024

Impaired balance between coronary blood flow and myocardial metabolism in postpartum swine.

Selina M Tucker, Salman I Essajee, Cooper M Warne, Gregory M Dick, Michael P Heard, Nicole Crowe, Styliani Goulopoulou, Johnathan D Tune

Abstract read
In one paragraph

Article in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Selina M TuckerDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States of America.
Salman I EssajeeDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States of America.
Cooper M WarneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States of America.
Gregory M DickDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States of America.
Michael P HeardDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States of America.
Nicole CroweDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States of America.
Styliani GoulopoulouLawrence D. Longo, MD Center for Perinatal Biology, Departments of Basic Sciences, Gynecology and Obstetrics Loma Linda University, Loma Linda, CA, United States of America.
Johnathan D TuneDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States of America. Electronic address: johnathan.tune@unthsc.edu.

Funding

Disentangling the Mechanisms of Coronary Blood Flow Regulation through Multi-scale ModelingR01HL158723 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A, FIGUEROA, CARLOS ALBERTO · 2022 to 2025
$2.7M
American Heart Association-American Stroke Association 23PRE1012811NHLBI NIH HHS R01 HL158723
6 · The paper itself

Abstract

Understanding of the mechanisms contributing to the increased maternal susceptibility for major adverse cardiovascular events in the postpartum period remains poor. Accordingly, this study tested the hypothesis that the balance between coronary blood flow and myocardial metabolism is compromised during the puerperium period (35-45 days post-delivery) in swine. Systemic and coronary hemodynamic responses were assessed in anesthetized, open-chest control (nonpregnant) and puerperium/postpartum swine at baseline and in response to intravenous infusion of dobutamine (1-30 μg/kg/min). Blood pressure and heart rate were lower in postpartum swine at baseline and in response to dobutamine (P < 0.05). Coronary blood flow and myocardial oxygen delivery were significantly diminished at baseline in postpartum swine (P < 0.001), which corresponded with ∼35% reduction in myocardial oxygen consumption (MVO

Indexed as

Coronary CirculationMyocardiumPostpartum PeriodAnimalsBlood PressureDobutamineFemaleHeart RateHemodynamicsOxygen ConsumptionPregnancySwineDobutamineCoronary circulationMyocardial ischemiaPostpartum

Identifiers

PMID38971217
PMCPMC12676954

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.