Evidence map›Paper›PMID 38971178›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Pneumococcal infective endocarditis in Brazil: a multicenter study on a severe condition.

Roxana Flores Mamani, Rinaldo Focaccia Siciliano, Claudio Querido Fortes, Paulo Vieria Damasco, Cristiane da Cruz Lamas

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Roxana Flores MamaniFundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brazil.
Rinaldo Focaccia SicilianoUniversidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas (HCFMUSP), Instituto do Coração (InCor), São Paulo, SP, Brazil.
Claudio Querido FortesUniversidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.
Paulo Vieria DamascoUniversidade do Estado do Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil; Universidade Federal do Estado do Rio de Janeiro (Unirio), Rio de Janeiro, RJ, Brazil.
Cristiane da Cruz LamasFundação Oswaldo Cruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brazil; Instituto Nacional de Cardiologia, Rio de Janeiro, RJ, Brazil. Electronic address: cristiane.lamas@ini.fiocruz.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStreptococcus pneumoniae bacteremia may result in Infective Endocarditis (IE). In the pre-antibiotic era, it caused 10 %‒15 % of IE, decreasing to < 3 % after penicillin availability. Although infrequent, it causes aggressive disease.

methodsRetrospective analysis of endocarditis databases, prospectively implemented in 4 Brazilian institutions, 2005‒2023.

resultsFrom the prospective cohorts comprising 2321 adult patients with IE, we identified 11 (0.47%) with pneumococcal IE. Males represented 7/11 and mean age was 54 years (22‒77). All had native valve involvement; perivalvular abscess was present in 6/11. Only one patient had concurrent meningitis. Beta-lactams were the antibiotics used in 10/11. All had surgical indication, but only 6 had it, as the others were seriously ill. Overall, in hospital mortality was 6/11, but only 1/6 of those who underwent surgery died, compared to 5/5 of those who had an indication for surgery and did not have it.

conclusionsThe high mortality rates and need for surgical intervention emphasize the need to promptly identify and manage pneumococcal endocarditis. Physicians ought to recommend vaccination to all patients at risk for severe pneumococcal disease.

Indexed as

Endocarditis, BacterialPneumococcal InfectionsAdultAgedAnti-Bacterial AgentsBrazilFemaleHospital MortalityHumansMaleMiddle AgedProspective StudiesRetrospective StudiesRisk FactorsSeverity of Illness IndexStreptococcus pneumoniaeAnti-Bacterial AgentsInfective endocarditisMortalityStreptococcus pneumoniaeSurgery

Identifiers

PMID38971178
PMCPMC11304691

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.