Evidence map›Paper›PMID 38970922›Full record

ArticleCell calcium2024

ER and SOCE Ca

Alberto Granzotto, Amanda McQuade, Jean Paul Chadarevian, Hayk Davtyan, Stefano L Sensi, Ian Parker, Mathew Blurton-Jones, Ian F Smith

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alberto GranzottoUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States; Center for Advanced Sciences and Technology (CAST), University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Department of Neuroscience, Imaging and Clinical Sciences, University G d'Annunzio of Chieti-Pescara, Chieti, Italy. Electronic address: alberto.granzotto@unich.it.
Amanda McQuadeUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, United States; Department of Neurobiology and Behavior, University of California, Irvine, CA, United States; Institute for Neurodegenerative Diseases, University of California, San Francisco, CA, United States.
Jean Paul ChadarevianUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, United States; Department of Neurobiology and Behavior, University of California, Irvine, CA, United States.
Hayk DavtyanUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, United States.
Stefano L SensiCenter for Advanced Sciences and Technology (CAST), University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy; Department of Neuroscience, Imaging and Clinical Sciences, University G d'Annunzio of Chieti-Pescara, Chieti, Italy; Institute for Advanced Biomedical Technologies (ITAB), "G. d'Annunzio" University, Chieti-Pescara, Italy.
Ian ParkerDepartment of Neurobiology and Behavior, University of California, Irvine, CA, United States; Department of Physiology and Biophysics, University of California, Irvine, CA, United States.
Mathew Blurton-JonesUCI Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, United States; Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, CA, United States; Department of Neurobiology and Behavior, University of California, Irvine, CA, United States; Institute for Immunology, University of California, Irvine, CA, United States.
Ian F SmithDepartment of Neurobiology and Behavior, University of California, Irvine, CA, United States.

Funding

UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9M
Project 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Takahisa Kanekiyo · 2021 to 2026
$42.0M
The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Mathew Mark Blurton-Jones · 2020 to 2026
$27.9M
Elementary Events of Intracellular Calcium SignalingR37GM048071 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI PARKER, IAN · 2011 to 2020
$5.3M
Training in Translational ADRD Neuroscience (TITAN)T32AG073088 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2021 to 2026
$2.2M
ENGINEERED HUMAN MICROGLIA AS A CELL-BASED THERAPY FOR A-BETA PLAQUE REMOVALR21AG073787 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI BLURTON-JONES, MATHEW MARK · 2021 to 2022
$424k
NIA NIH HHS P30 AG066519NIA NIH HHS R21 AG073787NIA NIH HHS T32 AG073088NIA NIH HHS U19 AG069701NIA NIH HHS U54 AG054349NIGMS NIH HHS R37 GM048071
6 · The paper itself

Abstract

The central nervous system (CNS) is constantly surveilled by microglia, highly motile and dynamic cells deputed to act as the first line of immune defense in the brain and spinal cord. Alterations in the homeostasis of the CNS are detected by microglia that respond by extending their processes or - following major injuries - by migrating toward the affected area. Understanding the mechanisms controlling directed cell migration of microglia is crucial to dissect their responses to neuroinflammation and injury. We used a combination of pharmacological and genetic approaches to explore the involvement of calcium (Ca

Indexed as

CalciumCalcium SignalingCell MovementEndoplasmic ReticulumInduced Pluripotent Stem CellsMicrogliaChemotaxisCyclic AMPHumansCalciumCyclic AMPADPATPCalcium signalingEndoplasmic reticulumInflammationMigrationMotilityORAIP2RY12P2RY13Purinergic signalingSTIMStore-operated calcium entry

Identifiers

PMID38970922
PMCPMC12424127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.