Evidence map›Paper›PMID 38970823›Full record

ArticleEpigenetics2024

TET1 displays catalytic and non-catalytic functions in the adult mouse cortex.

Yee Hoon Foong, Blake Caldwell, Joanne L Thorvaldsen, Christopher Krapp, Clementina A Mesaros, Wanding Zhou, Rahul M Kohli, Marisa S Bartolomei

Abstract read
In one paragraph

Article in Epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yee Hoon FoongDepartment of Cell and Developmental Biology, Perelman School of Medicine, Smilow Center for Translational Research, Philadelphia, PA, USA.
Blake CaldwellDepartment of Cell and Developmental Biology, Perelman School of Medicine, Smilow Center for Translational Research, Philadelphia, PA, USA.
Joanne L ThorvaldsenDepartment of Cell and Developmental Biology, Perelman School of Medicine, Smilow Center for Translational Research, Philadelphia, PA, USA.
Christopher KrappDepartment of Cell and Developmental Biology, Perelman School of Medicine, Smilow Center for Translational Research, Philadelphia, PA, USA.
Clementina A MesarosTranslational Biomarkers Core, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wanding ZhouDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Rahul M KohliDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Marisa S BartolomeiDepartment of Cell and Developmental Biology, Perelman School of Medicine, Smilow Center for Translational Research, Philadelphia, PA, USA.ORCID 0000-0001-9410-5222

Funding

Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI A. Clementina Mesaros · 2006 to 2026
$35.3M
SEQUENCES CONTROLLING H19 GENE IMPRINTINGR01GM051279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 1994 to 2024
$5.1M
Ultra low-input epigenetic sequencing with combined enzymatic and long-read technologiesR01HG010646 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI Gang Fang, Rahul Manu Kohli · 2019 to 2026
$3.9M
Decoding Single-cell DNA Methylomes for Epigenetic Cell IdentityR35GM146978 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Wanding Zhou · 2022 to 2026
$2.2M
The mechanism and modulation of 5-methylcytosine oxidation by TET family enzymesR01GM118501 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI KOHLI, RAHUL MANU · 2017 to 2020
$1.2M
Role of TET1 in germ cell reprogramming and developmentR01GM146388 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BARTOLOMEI, MARISA S. · 2022 to 2025
$1.2M
Investigating the roles of active DNA demethylation pathways in epigenetic reprogrammingF31HD098764 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI CALDWELL, BLAKE ALEXANDER · 2019 to 2021
$93k
NHGRI NIH HHS R01 HG010646NICHD NIH HHS F31 HD098764NIEHS NIH HHS P30 ES013508NIGMS NIH HHS R01 GM051279NIGMS NIH HHS R01 GM118501NIGMS NIH HHS R01 GM146388NIGMS NIH HHS R35 GM146978
6 · The paper itself

Abstract

TET1/2/3 dioxygenases iteratively demethylate 5-methylcytosine, beginning with the formation of 5-hydroxymethylcytosine (5hmC). The post-mitotic brain maintains higher levels of 5hmC than most peripheral tissues, and TET1 ablation studies have underscored the critical role of TET1 in brain physiology. However, deletion of

Indexed as

5-MethylcytosineCerebral CortexDNA MethylationProto-Oncogene ProteinsAnimalsCpG IslandsDNA-Binding ProteinsMiceMice, KnockoutMutation5-hydroxymethylcytosine5-MethylcytosineDNA-Binding ProteinsProto-Oncogene ProteinsTET1 protein, mouseadult mouse cortexdioxygenasesDNA demethylationDNA hydroxymethylcytosineInfinium BeadChip arrayTET1

Identifiers

PMID38970823
PMCPMC11229741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.