Evidence map›Paper›PMID 38970708›Full record

ArticlePediatric radiology2024

Feasibility and success of a non-sedated brain MRI training protocol in 7-year-old children from rural and semi-rural Colombia.

Elizabeth Corn, Regan Andringa-Seed, Meagan E Williams, Margarita Arroyave-Wessel, Raul Tarud, Gilbert Vezina, Robert H Podolsky, Kushal Kapse, Catherine Limperopoulos, Madison M Berl and 2 more

Registry-linked trialAbstract read
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In one paragraph

Article in Pediatric radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04398901 (Developmental Outcome After In Utero ZIKV Exposure in Children Without Congenital Zika Syndrome), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04398901 enrolling by invitationnot on this map

Developmental Outcome After In Utero ZIKV Exposure in Children Without Congenital Zika Syndrome

TypeobservationalSponsorChildren's National Research InstituteRan2020 to 2025Enrolled204ConditionsZika Virus, Congenital Zika Syndrome, Congenital Infection, Child DevelopmentArmsNeurodevelopmental assessments
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Elizabeth CornZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0000-0001-7363-722X
Regan Andringa-SeedZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0009-0003-1937-2349
Meagan E WilliamsZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0000-0002-4346-0117
Margarita Arroyave-WesselZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0000-0001-8054-5788
Raul TarudSabbag Radiólogos, Barranquilla, Colombia.
Gilbert VezinaDivision of Diagnostic Imaging and Radiology, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0000-0002-1999-336X
Robert H PodolskyDivision of Biostatistics and Study Methodology, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0000-0003-3547-8859
Kushal KapseDeveloping Brain Institute, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0000-0001-8363-5404
Catherine LimperopoulosZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0000-0003-1735-0069
Madison M BerlDivision of Pediatric Neuropsychology, Children's National Hospital, Washington DC, USA.ORCID http://orcid.org/0000-0002-2469-1518
Carlos CureBIOMELab, Barranquilla, Colombia.ORCID http://orcid.org/0000-0002-3011-8814
Sarah B MulkeyZickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington DC, USA. sbmulkey@childrensnational.org.ORCID http://orcid.org/0000-0002-8084-526X

Funding

Neurobehavioral Evaluation CoreP50HD105328 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI WILLIAM Davis GAILLARD · 2021 to 2026
$9.3M
Childhood Outcome After In Utero ZIKV ExposureR01HD102445 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI MULKEY, SARAH BETH · 2020 to 2024
$3.6M
Eunice Kennedy Shriver National Institute of Child Health and Human Development R01HD102445NICHD NIH HHS P50 HD105328NICHD NIH HHS R01 HD102445NIH HHS P50HD105328
6 · The paper itself

Abstract

backgroundBrain magnetic resonance imaging (MRI) is a crucial tool for clinical evaluation of the brain and neuroscience research. Obtaining successful non-sedated MRI in children who live in resource-limited settings may be an additional challenge.

objectiveTo present a feasibility study of a novel, low-cost MRI training protocol used in a clinical research study in a rural/semi-rural region of Colombia and to examine neurodevelopmental factors associated with successful scans. MATERIALS AND

methodsFifty-seven typically developing Colombian children underwent a training protocol and non-sedated brain MRI at age 7. Group training utilized a customized booklet, an MRI toy set, and a simple mock scanner. Children attended MRI visits in small groups of two to three. Resting-state functional and structural images were acquired on a 1.5-Tesla scanner with a protocol duration of 30-40 minutes. MRI success was defined as the completion of all sequences and no more than mild motion artifact. Associations between the Wechsler Preschool and Primary Scale of Intelligence (WPPSI), Movement Assessment Battery for Children (MABC), Behavioral Rating Inventory of Executive Function (BRIEF), Child Behavior Checklist (CBCL), and Adaptive Behavior Assessment System (ABAS) scores and MRI success were analyzed.

resultsMean (SD) age at first MRI attempt was 7.2 (0.2) years (median 7.2 years, interquartile range 7.1-7.3 years). Twenty-six (45.6%) participants were male. Fifty-one (89.5%) children were successful across two attempts; 44 (77.2%) were successful on their first attempt. Six (10.5%) were unsuccessful due to refusal or excessive motion. Age, sex, and scores across all neurodevelopmental assessments (MABC, TVIP, ABAS, BRIEF, CBCL, NIH Toolbox Flanker, NIH Toolbox Pattern Comparison, WPPSI) were not associated with likelihood of MRI success (P=0.18, 0.19, 0.38, 0.92, 0.84, 0.80, 1.00, 0.16, 0.75, 0.86, respectively).

conclusionThis cohort of children from a rural/semi-rural region of Colombia demonstrated comparable MRI success rates to other published cohorts after completing a low-cost MRI familiarization training protocol suitable for low-resource settings. Achieving non-sedated MRI success in children in low-resource and international settings is important for the continuing diversification of pediatric research studies.

Indexed as

Feasibility StudiesMagnetic Resonance ImagingRural PopulationBrainChildColombiaFemaleHumansMaleLatin AmericaLow-resourceMRI preparationNeuroimagingNon-sedated MRI

Identifiers

PMID38970708
PMCPMC11482647

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Registered trials

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