Evidence map›Paper›PMID 38970508›Full record

ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2024

EGR3 reduces podocyte inflammatory damage in obesity related glomerulopathy by inhibiting the PRMT1

Lin Peng, Xiaoying Sun, Xuan Yi, Zhouqi Wang, Ke Chen

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Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Lin PengDepartment of Nephrology, First Hospital of Changsha, Changsha 410005. plin1018@163.com.
Xiaoying SunDepartment of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Xuan YiDepartment of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Zhouqi WangDepartment of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China.
Ke ChenDepartment of Endocrinology, Third Xiangya Hospital, Central South University, Changsha 410013, China. chenke520@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesObesity related glomerulopathy (ORG) is induced by obesity, but the pathogenesis remains unclear. This study aims to investigate the expression of early growth response protein 3 (EGR3) in the renal cortex tissues of ORG patients and high-fat diet-induced obese mice, and to further explore the molecular mechanism of EGR3 in inhibiting palmitic acid (PA) induced human podocyte inflammatory damage.

methodsRenal cortex tissues were collected from ORG patients (

resultsEGR3 was significantly upregulated in renal cortex tissues of ORG patients and high-fat diet-induced obese mice (both

conclusionsEGR3 may reduce ORG podocyte inflammatory damage by inhibiting the PRMT1/p-STAT3 pathway.

Indexed as

Early Growth Response Protein 3ObesityPodocytesProtein-Arginine N-MethyltransferasesRepressor ProteinsSTAT3 Transcription FactorAnimalsDiet, High-FatHumansInflammationInterleukin-1betaInterleukin-6Kidney CortexKidney DiseasesMaleMiceEarly Growth Response Protein 3EGR3 protein, humanEgr3 protein, mouseInterleukin-1betaInterleukin-6Palmitic AcidPRMT1 protein, humanPrmt1 protein, mouseProtein-Arginine N-MethyltransferasesRepressor ProteinsSTAT3 protein, humanSTAT3 Transcription Factorearly growth response protein 3inflammatory factorsobesity related nephropathypalmitic acidpodocyte

Identifiers

PMID38970508
PMCPMC11208401

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