Evidence map›Paper›PMID 38970228›Full record

ArticlePhotochemistry and photobiology

Therapeutic effect of NEO400, perillyl alcohol conjugated to linoleic acid, in a mouse model of UV-induced skin damage.

Stephen Swenson, Catalina Silva-Hirschberg, Liliana Freeland, Kristen L Chen, Nagore I Marín-Ramos, Axel H Schönthal, Thomas C Chen

Abstract read
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In one paragraph

Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephen SwensonDepartment of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-1366-1871
Catalina Silva-HirschbergDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Liliana FreelandDepartment of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Kristen L ChenDepartment of Dermatology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0002-0361-9234
Nagore I Marín-RamosDepartment of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-4712-0934
Axel H SchönthalDepartment of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0003-0662-5653
Thomas C ChenDepartment of Neurosurgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.ORCID 0000-0002-2183-4667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive exposure to ultraviolet radiation (UVR) causes harmful effects on human skin. Pre-exposure application of sunscreen can be protective, but not after damage already has occurred. There is a need for agents that can be applied post-UVR exposure to repair the damage. We investigated a novel compound, NEO400, that appears to meet this medicinal need. NEO400 was created by conjugating linoleic acid to perillyl alcohol. UVR was repeatedly administered to the skin of mice over several weeks, where it caused the typical signs of UV damage, including scaling of the skin, DNA damage, and elevated levels of inflammatory cytokines. However, when NEO400 was applied immediately post-UVR, it triggered the appearance of markers for dermal stem cell proliferation, and no signs of skin damage emerged. Furthermore, when NEO400 was applied to skin that already had incurred significant damage, it accelerated skin healing. When applied individually, linoleic acid and perillyl alcohol were ineffective, indicating that they had to be conjugated in order to exert therapeutic efficacy. None of these skin-protective effects could be achieved with Aloe vera gel, a popular and widely used post-exposure remedy. Our study suggests that NEO400 holds potential as a regenerative treatment for excessively UVR-exposed skin.

Indexed as

Linoleic AcidMonoterpenesSkinUltraviolet RaysAnimalsDisease Models, AnimalDNA DamageFemaleMiceLinoleic AcidMonoterpenesperillyl alcoholAloe veralinoleic acidperillyl alcoholskin damageUV radiation

Identifiers

PMID38970228
PMCPMC11913761

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.