Evidence map›Paper›PMID 38970167›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Short-Term Statin Therapy Induces Hepatic Insulin Resistance Through HNF4α/PAQR9/PPM1α Axis Regulated AKT Phosphorylation.

Yijun Lin, Shuying Wang, Zixuan Li, Yuling Zhou, Ruiying Wang, Yan Wang, Yan Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yijun LinXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, 361016, China.ORCID 0009-0004-6330-0593
Shuying WangCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Zixuan LiCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
Yuling ZhouXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, 361016, China.
Ruiying WangXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, 361016, China.
Yan WangXiamen Cardiovascular Hospital, School of Medicine, Xiamen University, Xiamen, 361016, China.
Yan ChenCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.

Funding

Fujian Municipal Health Commission 2023QNB005National Natural Science Foundation of China 82300899
6 · The paper itself

Abstract

Statins, the first-line medication for dyslipidemia, are linked to an increased risk of type 2 diabetes. But exactly how statins cause diabetes is yet unknown. In this study, a developed short-term statin therapy on hyperlipidemia mice show that hepatic insulin resistance is a cause of statin-induced diabetes. Statin medication raises the expression of progesterone and adiponectin receptor 9 (PAQR9) in liver, which inhibits insulin signaling through degradation of protein phosphatase, Mg

Indexed as

Hepatocyte Nuclear Factor 4Hydroxymethylglutaryl-CoA Reductase InhibitorsInsulin ResistanceLiverSignal TransductionAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLPhosphorylationProtein Phosphatase 2CProto-Oncogene Proteins c-aktHepatocyte Nuclear Factor 4Hnf4a protein, mouseHydroxymethylglutaryl-CoA Reductase InhibitorsPpm1a protein, mouseProtein Phosphatase 2CProto-Oncogene Proteins c-aktAKT phosphorylationhepatic insulin resistanceprogesterone and adiponectin receptor 9 (PAQR9)statinstype 2 diabetes

Identifiers

PMID38970167
PMCPMC11425881

What OpenQuestion holds

Texttitle and abstract
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.