Evidence map›Paper›PMID 38970153›Full record

ArticleClinical and translational allergy2024

Comparison of skin prick test and prick-to-prick test with fruits and vegetables in the diagnosis of food allergy.

Severina Terlouw, Frank E van Boven, Monika Borsboom-van Zonneveld, Tineke de Graaf-In 't Veld, Roy Gerth van Wijk, Paul L A van Daele, Maurits S van Maaren, Jac H S A M Kuijpers, Sharon Veenbergen, Nicolette W de Jong

Registry-linked trialAbstract read
In one paragraph

Article in Clinical and translational allergy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06872996 (Trophallergen Prick Tests), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06872996 narecruitingnot on this mapstarted 2025, after this paper: background citation

Trophallergen Prick Tests (PT) : Influence of Food Sample Shelf Life on the Reproducibility of PT Results

TypeinterventionalSponsorCentre Hospitalier Régional d'OrléansRan2025 to 2027Enrolled100ConditionsFood AllergyArmsPrick-test
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Severina TerlouwDepartment of Allergology, Albert Schweitzer Hospital, Zwijndrecht, The Netherlands.
Frank E van BovenInternal Medicine, Allergology & Clinical Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0001-6520-1477
Monika Borsboom-van ZonneveldDepartment of Allergology, Albert Schweitzer Hospital, Zwijndrecht, The Netherlands.
Tineke de Graaf-In 't VeldDepartment of Allergology, Albert Schweitzer Hospital, Zwijndrecht, The Netherlands.
Roy Gerth van WijkInternal Medicine, Allergology & Clinical Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Paul L A van DaeleInternal Medicine, Allergology & Clinical Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Maurits S van MaarenInternal Medicine, Allergology & Clinical Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-5241-8869
Jac H S A M KuijpersDepartment of Immunology, Laboratory Medical Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Sharon VeenbergenDepartment of Immunology, Laboratory Medical Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Nicolette W de JongInternal Medicine, Allergology & Clinical Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.ORCID https://orcid.org/0000-0002-7216-0906

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPrick-to-prick (PTP) test with fresh food is accepted as a reliable tool for measuring sensitization to fruits and vegetables. Not all fruits and vegetables are available throughout the year. The objective of this study was to investigate whether skin prick test (SPT) performed with frozen juice of fruits and vegetables (FJFV) is a good alternative to PTP tests performed with fresh fruits and vegetables (FFV).

methodsAdult patients suspected of having a food allergy to fruits and/or vegetables were included. A questionnaire was used to score symptoms after consumption of apple, kiwi, peach, tomato, and carrot. SPTs with FJFV, and PTP tests with FFV were performed. Intra-class correlation coefficients (ICC) between the SPT and PTP test results were calculated. The sensitivity and specificity of both diagnostic tests towards food allergen specific symptoms (FASS) were calculated.

resultsThirty-six patients were included. FASS was positive in 75% for apple, 53% for kiwi, 44% for peach, 25% for tomato, and 22% for carrot. ICC between SPT and PTP test results were moderate for apple (0.72) and kiwi (0.71), strong for peach (0.75) and tomato (0.89), and very strong for carrot (0.94). Sensitivity was equal for the SPT and PTP tests for apple (0.93), peach (0.81), and carrot (1.00), and comparable for kiwi (0.50 resp. 0.70), and tomato (0.44 resp. 0.56). Specificity was equal for apple (0.33), peach (0.15), and carrot (0.41), and comparable for kiwi (0.29 resp. 0.21) and tomato (0.80 resp. 0.72).

conclusionsResults of SPT with FJFV and PTP test with FFV are comparable. SPT with FJFV is a good alternative in the daily practice of the allergists.

Indexed as

diagnosisfood allergyhomemade extractsprick‐to‐prick testskin prick test

Identifiers

PMID38970153
PMCPMC11226404

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.