SynthesisInfectious diseases of poverty2024
Discrepancies between self-reported medication in adherence and indirect measurement adherence among patients undergoing antiretroviral therapy: a systematic review.
Synthesis in Infectious diseases of poverty, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- HIV-tuberculosis co-infection in Liangshan, a resource-limited region of Southwest China: trends and implications in the context of integrated prevention, 2019-2024.Infectious diseases of poverty · 2026Article
- Parallel declines in antiretroviral therapy adherence by dried blood spot and electronic monitoring in Cape Town, South Africa.AIDS (London, England) · 2026Article
- Evolution of ART Medication Adherence Support and Monitoring Across IeDEA Sites: Results From Three Waves of Consortium-Wide Site Assessment Surveys, 2017, 2020 and 2023.Journal of the International AIDS Society · 2026Article
- When medical knowledge is not enough: medication adherence and self-treatment among physicians with chronic illness in Upper Egypt.Discover mental health · 2026Article
- Knowledge, Psychological Distress, and Medication Beliefs Among Tuberculosis Patients in Southwest China: A Mediation Analysis.Healthcare (Basel, Switzerland) · 2026Article
- A Scoping Review Assessing the Relationship Between Structural, Functional, and Perceived Social Support with Antiretroviral Therapy (ART) in the Last Decade.AIDS and behavior · 2026Article
- The Impact of the Multidisciplinary Team on Medication Adherence in Type 2 Diabetes: A Narrative Review.Journal of multidisciplinary healthcare · 2026Review
- Review of clinical medication adherence in patients with schizophrenia.World journal of psychiatry · 2025Review
- Article
- Usability of a website to promote treatment adherence for adults with HIV.Investigacion y educacion en enfermeria · 2025Article
- Application of causal forest double machine learning (DML) approach to assess tuberculosis preventive therapy's impact on ART adherence.Scientific reports · 2025Article
- Determinants of Non-Adherence to Anti-Tuberculosis Treatment in a Public Primary Healthcare Clinic in South Africa: Improving the Quality of Long-Term Care.International journal of environmental research and public health · 2025Article
- [ART adherence and its association with depression, anxiety and stress].Revista medica del Instituto Mexicano del Seguro Social · 2025Observational
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundGiven the critical importance of medication adherence in HIV/AIDS treatment, this study aims to compare medication adherence measured by self-report (SR) and indirect measurement among antiretroviral therapy (ART) patients, exploring the differences of adherence results measured by different tools.
methodsWe systematically searched PubMed, Embase, and the Cochrane Library to identify all relevant literature published up to November 22, 2023, without language restrictions, reporting adherence to ART measured by both SR and indirect measurement methods, while also analyzing individual and group adherence separately. Discrepancies between SR and indirect measurement results were assessed using the Mann-Whitney U test or Wilcoxon signed-rank test, with correlations evaluated using the Pearson correlation coefficient. Following one-to-one comparisons, meta-epidemiological one-step analysis was conducted, and network meta-analysis techniques were applied to compare results obtained through specific adherence assessment tools reported in the identified articles.
resultsThe analysis encompassed 65 original studies involving 13,667 HIV/AIDS patients, leading to 112 one-to-one comparisons between SR and indirect measurement tools. Statistically significant differences were observed between SR and indirect measurement tools regarding both individual and group adherence (P < 0.05), with Pearson correlation coefficients of 0.843 for individual adherence and 0.684 for group adherence. During meta-epidemiological one-step analysis, SR-measured adherence was determined to be 3.94% (95% CI: -4.48-13.44%) higher for individual adherence and 16.14% (95% CI: 0.81-18.84%) higher for group adherence compared to indirectly measured results. Subgroup analysis indicated that factors such as the year of reporting and geographic region appeared to influence the discrepancies between SR and indirect measurements. Furthermore, network meta-analysis revealed that for both individual and group adherence, the results obtained from most SR and indirect measurement tools were higher than those from electronic monitoring devices, with some demonstrating statistical significance (P < 0.05).
conclusionsThe findings underscored the complexity of accurately measuring medication adherence among ART patients. Significant variability was observed across studies, with self-report methods showing a significant tendency towards overestimation. Year of reporting, geographic region, and adherence measurement tools appeared to influence the differences between SR and indirect measurements. Future research should focus on developing and validating integrated adherence measurements that can combine SR data with indirect measures to achieve a more comprehensive understanding of adherence behaviors.
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