Evidence map›Paper›PMID 38970102›Full record

ArticleJournal of pharmaceutical health care and sciences2024

Development of an HPLC method using relative molar sensitivity for the measurement of blood concentrations of nine pharmaceutical compounds.

Takashi Ohtsuki, Yi Huang, Ayane Kamiya, Yuki Nakayama, Miyuki Matsushita, Satoru Morikawa, Hiroshi Matsufuji

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical health care and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takashi OhtsukiDepartment of Food Science and Technology, College of Bioresource Sciences, Nihon University, Kameino, Fujisawa, 1866, Kanagawa, Japan. ohtsuki.takashi@nihon-u.ac.jp.
Yi HuangDepartment of Food Science and Technology, College of Bioresource Sciences, Nihon University, Kameino, Fujisawa, 1866, Kanagawa, Japan.
Ayane KamiyaDepartment of Food Science and Technology, College of Bioresource Sciences, Nihon University, Kameino, Fujisawa, 1866, Kanagawa, Japan.
Yuki NakayamaDepartment of Food Science and Technology, College of Bioresource Sciences, Nihon University, Kameino, Fujisawa, 1866, Kanagawa, Japan.
Miyuki MatsushitaHitachi High-Tech Science Corporation, 1-17-1, Toranomon, Minato-ku, Tokyo, Japan.
Satoru MorikawaHitachi High-Tech Science Corporation, 1-17-1, Toranomon, Minato-ku, Tokyo, Japan.
Hiroshi MatsufujiDepartment of Food Science and Technology, College of Bioresource Sciences, Nihon University, Kameino, Fujisawa, 1866, Kanagawa, Japan.

Funding

Japan Society for the Promotion of Science 21K05430
6 · The paper itself

Abstract

We developed a reliable high-performance liquid chromatographic analysis method using a relative molar sensitivity (RMS) technique that does not require an authentic, identical reference analyte material to quantify blood serum carbamazepine, phenytoin, voriconazole, lamotrigine, meropenem, mycophenolic acid, linezolid, vancomycin, and caffeine levels for routine blood concentration measurements. Carbamazepine and caffeine were also used as non-analyte reference materials to calculate the RMS of each analyte. The RMS was calculated from the ratio of the slope of the calibration equation (analyte/non-analyte reference material), then used to quantify analytes in control serum samples spiked with carbamazepine, phenytoin, voriconazole, meropenem, mycophenolic acid, linezolid or vancomycin. In addition, the concentrations of these six drugs in control serum samples determined by the proposed RMS method agreed well with that obtained using a conventional method. The proposed RMS method is a promising tool for the clinical determination of nine drugs, given the accuracy, precision, and efficiency of quantifying these analytes.

Indexed as

CaffeineCarbamazepineHPLCLamotrigineLinezolidMeropenemMycophenolic acidPhenytoinRelative molar sensitivityTherapeutic drug monitoringVancomycinVoriconazole

Identifiers

PMID38970102
PMCPMC11227149

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.