Evidence map›Paper›PMID 38970083›Full record

ArticleBioelectronic medicine2024

A multi-channel stimulator with an active electrode array implant for vagal-cardiac neuromodulation studies.

Fangqi Liu, Maryam Habibollahi, Yu Wu, Nazanin Neshatvar, Jiaxing Zhang, Ciro Zinno, Outman Akouissi, Fabio Bernini, Lisa Alibrandi, Khatia Gabisonia and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioelectronic medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Fangqi LiuDepartment of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Maryam HabibollahiDepartment of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Yu WuDepartment of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Nazanin NeshatvarDepartment of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Jiaxing ZhangDepartment of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Ciro ZinnoBioRobotics Institute, Scuola Superiore Sant'Anna (SSSA), 56025, Pisa, Italy.
Outman AkouissiEPFL, Campus Biotech, CH-1202, Geneva, Switzerland.
Fabio BerniniBioMedLab, Scuola Superiore Sant'Anna (SSSA), Pisa, Italy.
Lisa AlibrandiBioMedLab, Scuola Superiore Sant'Anna (SSSA), Pisa, Italy.
Khatia GabisoniaBioMedLab, Scuola Superiore Sant'Anna (SSSA), Pisa, Italy.
Vincenzo LionettiBioMedLab, Scuola Superiore Sant'Anna (SSSA), Pisa, Italy.
Jacopo CarpanetoBioRobotics Institute, Scuola Superiore Sant'Anna (SSSA), 56025, Pisa, Italy.
Henry LancashireDepartment of Medical Physics and Bioengineering, University College London, Gower Street, London, WC1E 6BT, UK.
Dai JiangDepartment of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK.
Silvestro MiceraBioRobotics Institute, Scuola Superiore Sant'Anna (SSSA), 56025, Pisa, Italy.
Andreas DemosthenousDepartment of Electronic and Electrical Engineering, University College London, Torrington Place, London, WC1E 7JE, UK. a.demosthenous@ucl.ac.uk.ORCID http://orcid.org/0000-0003-0623-963X

Funding

H2020 Future and Emerging Technologies 824071
6 · The paper itself

Abstract

backgroundImplantable vagus nerve stimulation is a promising approach for restoring autonomic cardiovascular functions after heart transplantation. For successful treatment a system should have multiple electrodes to deliver precise stimulation and complex neuromodulation patterns.

methodsThis paper presents an implantable multi-channel stimulation system for vagal-cardiac neuromodulation studies in swine species. The system comprises an active electrode array implant percutaneously connected to an external wearable controller. The active electrode array implant has an integrated stimulator ASIC mounted on a ceramic substrate connected to an intraneural electrode array via micro-rivet bonding. The implant is silicone encapsulated for biocompatibility and implanted lifetime. The stimulation parameters are remotely transmitted via a Bluetooth telemetry link.

resultsThe size of the encapsulated active electrode array implant is 8 mm × 10 mm × 3 mm. The stimulator ASIC has 10-bit current amplitude resolution and 16 independent output channels, each capable of delivering up to 550 µA stimulus current and a maximum voltage of 20 V. The active electrode array implant was subjected to in vitro accelerated lifetime testing at 70 °C for 7 days with no degradation in performance. After over 2 h continuous stimulation, the surface temperature change of the implant was less than 0.5 °C. In addition, in vivo testing on the sciatic nerve of a male Göttingen minipig demonstrated that the implant could effectively elicit an EMG response that grew progressively stronger on increasing the amplitude of the stimulation.

conclusionsThe multi-channel stimulator is suitable for long term implantation. It shows potential as a useful tool in vagal-cardiac neuromodulation studies in animal models for restoring autonomic cardiovascular functions after heart transplantation.

Indexed as

Active electrode arrayImplant fabricationIntegrated stimulatorMicroelectrodesNeuroprosthesisVagus nerve stimulator

Identifiers

PMID38970083
PMCPMC11227238

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.