ArticleCritical care (London, England)2024
Calcium supplementation during trauma resuscitation: a propensity score-matched analysis from the TraumaRegister DGU
Article in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
8 citing papers in PubMed.
- Admission ionised calcium disturbances and adverse outcomes in paediatric major trauma: a UK multicentre retrospective cohort study.BMJ open · 2026Article
- The Influence of Hypocalcaemia on Trauma Patients Experiencing Post-Induction Hypotension: A Retrospective Observational Study.Emergency medicine Australasia : EMA · 2026Observational
- The Importance of the "Damage Control" Strategy in Multiple Organ Injuries, Pathophysiology and Principles of Hemorrhage Control.Journal of clinical medicine · 2026Review
- Initial Calcium Derangements in Major Trauma and Outcomes.JAMA network open · 2026Article
- Just the facts: calcium administration in trauma patients receiving massive blood transfusions.CJEM · 2026Article
- Prehospital measurement and treatment of ionised hypocalcaemia by UK helicopter emergency medical services in trauma patients: a survey of current practice.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025Article
- Rethinking Balanced Resuscitation in Trauma.Journal of clinical medicine · 2025Review
- Calcium in major trauma: in search of the Holy Grail?Trauma surgery & acute care open · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn major trauma patients, hypocalcemia is associated with increased mortality. Despite the absence of strong evidence on causality, early calcium supplementation has been recommended. This study investigates whether calcium supplementation during trauma resuscitation provides a survival benefit.
methodsWe conducted a retrospective analysis using data from the TraumaRegister DGU
resultsWithin a cohort of 28,323 directly admitted adult major trauma patients at a European trauma center, 1593 (5.6%) received calcium supplementation. Using multivariable logistic regression to generate propensity scores, two comparable groups of 1447 patients could be matched. No significant difference in early mortality (6 h and 24 h) was observed, while in-hospital mortality appeared higher in those with calcium supplementation (28.3% vs. 24.5%, P = 0.020), although this was not significant when adjusted for predicted mortality (P = 0.244).
conclusionIn this matched cohort, no evidence was found for or against a survival benefit from calcium supplementation during trauma resuscitation. Further research should focus on understanding the dynamics and kinetics of ionized calcium levels in major trauma patients and identify if specific conditions or subgroups could benefit from calcium supplementation.
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