Evidence map›Paper›PMID 38969917›Full record

ReviewJournal of bioethical inquiry2024

Human Brain Organoid Research and Applications: Where and How to Meet Legal Challenges?

M Kataoka, T-L Lee, T Sawai

Abstract readReview
In one paragraph

Review in Journal of bioethical inquiry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

M KataokaGraduate School of Humanities and Social Sciences, Hiroshima University, Higashi-Hiroshima, Japan.ORCID 0000-0002-8687-0589
T-L LeeGraduate Institute of Health and Biotechnology Law, Taipei Medical University, Taipei, Taiwan.ORCID 0000-0002-8935-0247
T SawaiGraduate School of Humanities and Social Sciences, Hiroshima University, Higashi-Hiroshima, Japan. tstmsw@hiroshima-u.ac.jp.ORCID 0000-0002-3806-0573

Funding

Japan Agency for Medical Research and Development JP21wm0425021Japan Society for the Promotion of Science 21K12908JST Research Institute of Science and Technology for Society JPMJRS22J4Uehiro Foundation on Ethics and Education UEHIRO2023-0113
6 · The paper itself

Abstract

An ethical and legal framework is needed to regulate the rapidly developing human brain organoid research field properly. However, considering the legal issues involved in human brain organoid research remains underdeveloped and scattered. This article reviews the legal issues of human brain organoid research, grouping them into the following five broad themes: (1) consciousness, (2) legal status, (3) consent, (4) ownership, and (5) transplantation. The issues in each topic include both the urgent (e.g., appropriate forms of consent) and the speculative (e.g., protection of conscious human brain organoids). Therefore, we have attempted to be as explicit as possible about the timescale within which each issue will be realized and to prioritize each. Examining these issues has revealed legal issues specific to human brain organoid research and issues common to research in other fields. Further discussion of human brain organoid research from a legal perspective is needed in the future, considering discussions in related fields.

Indexed as

Biomedical ResearchBrainInformed ConsentOrganoidsConsciousnessHumansOwnershipBrain organoidsConsciousnessInformed consentOwnershipPersonhoodTransplantation

Identifiers

PMID38969917
PMCPMC11882709

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.