Evidence map›Paper›PMID 38969817›Full record

ArticleBiochemical genetics2025

The Relationship Between GAPDH Gene Polymorphism and Risk of Acute Coronary Syndrome in South Indians with Type 2 Diabetes Mellitus.

Sushmita Bora, Prashant Shankarrao Adole, Kolar Vishwanath Vinod, Ajith Ananthakrishna Pillai, Shaheer Ahmed

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Article in Biochemical genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Sushmita BoraDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.
Prashant Shankarrao AdoleDepartment of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India. prashant.adole@gmail.com.
Kolar Vishwanath VinodDepartment of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.
Ajith Ananthakrishna PillaiDepartment of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.
Shaheer AhmedDepartment of Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, 605006, India.

Funding

Indian Council Medical Research, New Delhi F.No.52/19/2020-BIO/BMS Dated 23/11/2021Jawaharlal Institute Of Postgraduate Medical Education and Research JIP/Res/Intramural/sub com/2020-21 dated 11/09/2020
6 · The paper itself

Abstract

As glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is one of the regulators of carbonyl stress, a pathogenic mechanism for diabetic complications like acute coronary syndrome (ACS), the study aimed to investigate the relationship between GAPDH gene polymorphism, GAPDH activity in red blood cell (RBC), methylglyoxal (MG) levels in plasma and ACS risk in South Indians with type 2 diabetes mellitus (T2DM). This study comprised 150 T2DM with ACS as cases and 150 T2DM without ACS as controls. The GAPDH rs1136666, rs1060620 and rs1060619 gene polymorphisms were identified by TaqMan probe assays. The RBC GAPDH activity and plasma MG levels were estimated. Cases had significantly higher plasma MG levels and lower RBC GAPDH activity than controls (P < 0.001). The distribution of rs1060620 or rs1060619 alleles and genotypes significantly differed between groups. The rs1060620 AG (OR 0.55; 95% CI 0.33-0.92; P = 0.022) or rs1060619 CT (OR 0.51; 95% CI 0.31-0.83; P = 0.007) genotype was associated with reduced ACS risk, confirmed in the over-dominant genetic model. Haplotype analyses revealed that the GAT and CGC haplotypes were associated with increased (OR 28.37; 95% CI 3.82-210.49; P = 8.51 × 10

Indexed as

Acute Coronary SyndromeDiabetes Mellitus, Type 2Glyceraldehyde-3-Phosphate DehydrogenasesPolymorphism, Single NucleotideAgedCase-Control StudiesFemaleGenetic Predisposition to DiseaseGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)HaplotypesHumansIndiaMaleMiddle AgedPyruvaldehydeRisk FactorsGAPDH protein, humanGlyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)Glyceraldehyde-3-Phosphate DehydrogenasesPyruvaldehydeAcute coronary syndromeCarbonyl stressGene polymorphismGlyceraldehyde-3-phosphate dehydrogenaseType 2 diabetes mellitus

Identifiers

PMID38969817

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