ArticleNature materials2024
Quantifying mechanical forces during vertebrate morphogenesis.
Article in Nature materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Mechanical stress remodelling drives epithelial-mesenchymal transition in the tumour microenvironment.Nature nanotechnology · 2026Article
- TiFM2.0 - versatile mechanical measurement and actuation in live embryos.Development (Cambridge, England) · 2026Article
- Noninvasive 3D mapping of tissue stress using reverberant shear wave.Nature communications · 2026Article
- Cell and tissue mechanics in 3-D organ morphogenesis: Insights from Drosophila pupal retina development.Developmental biology · 2026Review
- Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis.Current biology : CB · 2026Article
- Discovering the unexpected: Insights into the dynamics of mouse neural tube closure revealed by time-lapse imaging.Developmental biology · 2026Review
- MechanoMR microparticle (MbioRxiv : the preprint server for biology · 2025Article
- Synergistic mastery: Advancing mechanical and electrical harmony in conducting polymer hydrogel bioelectronics.Bioactive materials · 2025Article
- A Point-Line-Area Paradigm: 3D Printing for Next-Generation Health Monitoring Sensors.Sensors (Basel, Switzerland) · 2025Review
- Three-dimensional traction technology and its application in mechanomedicine.Mechanobiology in medicine · 2025Review
- Mechanical Behavior and Indentation-Induced Injury of Soft Microtissues with Different Densification Levels.ACS omega · 2025Article
- Measuring and manipulating mechanical forces during development.Nature cell biology · 2025Review
- The first embryo, the origin of cancer and animal phylogeny. V. Cancer stem cells as the unifying biomechanical principle between embryology and oncology.Mechanobiology in medicine · 2025Review
- Sensing the force in living embryos.Nature materials · 2024Article
- How growth-induced stresses guide shape changes during animal morphogenesis: Mechanisms and implications.Seminars in cell & developmental biologyReview
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
Morphogenesis requires embryonic cells to generate forces and perform mechanical work to shape their tissues. Incorrect functioning of these force fields can lead to congenital malformations. Understanding these dynamic processes requires the quantification and profiling of three-dimensional mechanics during evolving vertebrate morphogenesis. Here we describe elastic spring-like force sensors with micrometre-level resolution, fabricated by intravital three-dimensional bioprinting directly in the closing neural tubes of growing chicken embryos. Integration of calibrated sensor read-outs with computational mechanical modelling allows direct quantification of the forces and work performed by the embryonic tissues. As they displace towards the embryonic midline, the two halves of the closing neural tube reach a compression of over a hundred nano-newtons during neural fold apposition. Pharmacological inhibition of Rho-associated kinase to decrease the pro-closure force shows the existence of active anti-closure forces, which progressively widen the neural tube and must be overcome to achieve neural tube closure. Overall, our approach and findings highlight the intricate interplay between mechanical forces and tissue morphogenesis.
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