Evidence map›Paper›PMID 38969668›Full record

ArticleScientific reports2024

Spatially resolved imaging of human macular capillaries using adaptive optics-enhanced optical coherence tomography angiography.

S Bonnin, K Gocho, N Norberg, E Gofas, R Lejoyeux, C Chaumette, K Grieve, A Couturier, M Paques

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

S Bonnin *Paris Eye Imaging Group, Clinical Investigation Center Vision 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne University, 28 Rue de Charenton, 75012, Paris, France.
K Gocho *Paris Eye Imaging Group, Clinical Investigation Center Vision 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne University, 28 Rue de Charenton, 75012, Paris, France.
N NorbergParis Eye Imaging Group, Clinical Investigation Center Vision 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne University, 28 Rue de Charenton, 75012, Paris, France.
E GofasParis Eye Imaging Group, Clinical Investigation Center Vision 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne University, 28 Rue de Charenton, 75012, Paris, France.
R LejoyeuxRothschild Foundation Hospital, 25-29 Rue Manin, 75019, Paris, France.
C ChaumetteParis Eye Imaging Group, Clinical Investigation Center Vision 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne University, 28 Rue de Charenton, 75012, Paris, France.
K GrieveParis Eye Imaging Group, Clinical Investigation Center Vision 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne University, 28 Rue de Charenton, 75012, Paris, France.
A CouturierParis Eye Imaging Group, Clinical Investigation Center Vision 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne University, 28 Rue de Charenton, 75012, Paris, France.
M PaquesParis Eye Imaging Group, Clinical Investigation Center Vision 1423, Quinze-Vingts Hospital, INSERM-DHOS, Sorbonne University, 28 Rue de Charenton, 75012, Paris, France. mpaques@15-20.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Documenting the organization of the retinal capillaries is of importance to understand the visual consequences of vascular diseases which may differentially affect the microvascular layers. Here we detailed the spatial organization of the macular capillaries in ten healthy human subjects using a prototypic adaptive optics-enhanced optical coherence tomography angiography (AO-OCTA) system. Within the central 6° × 6°, the radial peripapillary capillaries and the superficial, intermediate and deep vascular plexuses (SVP, IVP and DVP, respectively) were consistently resolved. In 8 out of the 10 eyes, the capillary segments composing the perifoveal arcade (PFA) were perfused only by the SVP, while drainage of the PFA showed more variability, comprising a case in which the PFA was drained by the DVP. Around the center, a distinct central avascular zone could be documented for each layer in 7 of the 10 cases; in three eyes, the IVP and SVP merged tangentially around the center. In all eyes, the foveal avascular zone was larger in the DVP than in the SVP and IVP. In one eye with incomplete separation of the inner foveal layers, there was continuity of both the SVP and the IVP; a central avascular zone was only present in the DVP. The diversity of perfusion and drainage patterns supported a connectivity scheme combining parallel and serial organizations, the latter being the most commonly observed in perifoveal vessels. Our results thus help to further characterize the diversity of organization patterns of the macular capillaries and to robustly analyze the IVP, which will help to characterize early stages of microvascular diseases.

Indexed as

CapillariesRetinal VesselsTomography, Optical CoherenceAdultFemaleFluorescein AngiographyHumansMacula LuteaMaleMiddle AgedFoveaMaculaMicrocirculationOptical coherence tomography angiographyRetina

Identifiers

PMID38969668
PMCPMC11226425

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