ReviewTranslational psychiatry2024
Is depression a global brain disorder with topographic dynamic reorganization?
Review in Translational psychiatry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Altered neural activities during emotion regulation in depression: a meta-analysis.Journal of psychiatry & neuroscience : JPNPooled it
- Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPNPooled it
- Neurobiological influences on event perception: the role of catecholamines.The international journal of neuropsychopharmacology · 2025Trial
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Molecular and neural circuit mechanisms of parvalbumin (PV) neurons in depression: Insights and advances.iScience · 2026Review
- Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Multi-Site Transfer Classification of Major Depressive Disorder: An fMRI Study in 3335 Subjects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Validation of the Italian version of the Short Mood and Feelings Questionnaire (SMFQ) in a sample of adolescents.Italian journal of pediatrics · 2026Article
- Dynamics of thoughts-novel candidate marker for differential-diagnosis of mental disorders?Journal of psychiatry & neuroscience : JPN · 2026Review
- Same movies, different stories: aberrant brain state dynamics during naturalistic emotional stimuli in depression.Journal of translational medicine · 2025Article
- Unveiling the Multifaceted Networks of the Left DLPFC for Precision TMS Targeting.bioRxiv : the preprint server for biology · 2025Article
- Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study.BMC medicine · 2025Article
- Perturbing whole-brain models of brain hierarchy: An application for depression following pharmacological treatment.Annals of the New York Academy of Sciences · 2025Article
- Altered Global Signal Topography in Major Depressive Disorder With and Without Anxiety.Depression and anxiety · 2025Article
- Polygenic risk for depression and resting-state functional connectivity of subgenual anterior cingulate cortex in young adults.Journal of psychiatry & neuroscience : JPNArticle
- Beyond mood - depression as a speed disorder: biomarkers for abnormal slowness.Journal of psychiatry & neuroscience : JPNArticle
- Functional connectivity gradients and neurotransmitter maps among patients with mild cognitive impairment and depression symptoms.Journal of psychiatry & neuroscience : JPNArticle
- Correlation between polygenic risk scores of depression and cortical morphology networks.Journal of psychiatry & neuroscience : JPNArticle
- Interaction of the gut microbiota and brain functional connectivity in late-life depression.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
Abstract
Major depressive disorder (MDD) is characterized by a multitude of psychopathological symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal mechanisms underlying such co-occurrence of psychopathological symptoms remain yet unclear. Rather than linking and localizing single psychopathological symptoms to specific regions or networks, this perspective proposes a more global and dynamic topographic approach. We first review recent findings on global brain activity changes during both rest and task states in MDD showing topographic reorganization with a shift from unimodal to transmodal regions. Next, we single out two candidate mechanisms that may underlie and mediate such abnormal uni-/transmodal topography, namely dynamic shifts from shorter to longer timescales and abnormalities in the excitation-inhibition balance. Finally, we show how such topographic shift from unimodal to transmodal regions relates to the various psychopathological symptoms in MDD including their co-occurrence. This amounts to what we describe as 'Topographic dynamic reorganization' which extends our earlier 'Resting state hypothesis of depression' and complements other models of MDD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.