Evidence map›Paper›PMID 38969501›Full record

ArticleeNeuro2024

Adaptive Changes in Group 2 Metabotropic Glutamate Receptors Underlie the Deficit in Recognition Memory Induced by Methamphetamine in Mice.

Carla Letizia Busceti, Luisa Di Menna, Sonia Castaldi, Giovanna D'Errico, Alice Taddeucci, Valeria Bruno, Francesco Fornai, Anna Pittaluga, Giuseppe Battaglia, Ferdinando Nicoletti

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Intestinal inflammation induces glymphatic remodeling, priming early neurodegenerative signals in male mice.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  4. mGlu2 Receptors in the Basal Ganglia: A New Frontier in Addiction Therapy.Frontiers in bioscience (Landmark edition) · 2025
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Carla Letizia BuscetiDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli 86077, Italy.ORCID https://orcid.org/0000-0002-1417-1893
Luisa Di MennaDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli 86077, Italy.
Sonia CastaldiDepartment of Physiology and Pharmacology, University Sapienza, Roma 00185, Italy.
Giovanna D'ErricoDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli 86077, Italy.
Alice TaddeucciDepartment of Pharmacy, University of Genova, Genova 16148, Italy.
Valeria BrunoDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli 86077, Italy.
Francesco FornaiDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli 86077, Italy.
Anna PittalugaDepartment of Pharmacy, University of Genova, Genova 16148, Italy.
Giuseppe BattagliaDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli 86077, Italy.
Ferdinando NicolettiDepartment of Molecular Pathology, IRCCS Neuromed, Pozzilli 86077, Italy nicoletti@neuromed.it ferdinando.nicoletti@uniroma.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive dysfunction is associated with methamphetamine use disorder (MUD). Here, we used genetic and pharmacological approaches to examine the involvement of either Group 2 metabotropic glutamate (mGlu2) or mGlu3 receptors in memory deficit induced by methamphetamine in mice. Methamphetamine treatment (1 mg/kg, i.p., once a day for 5 d followed by 7 d of withdrawal) caused an impaired performance in the novel object recognition test in wild-type mice, but not in mGlu2

Indexed as

Central Nervous System StimulantsMethamphetamineMice, Inbred C57BLMice, KnockoutReceptors, Metabotropic GlutamateRecognition, PsychologyAnimalsMaleMemory DisordersMicePrefrontal CortexCentral Nervous System Stimulantsmetabotropic glutamate receptor 2metabotropic glutamate receptor 3MethamphetamineReceptors, Metabotropic GlutamateAGS3cognitive dysfunctionglutamate releasemetabotropic glutamate receptorsprefrontal cortexRab3A

Identifiers

PMID38969501
PMCPMC11298959

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.