Evidence map›Paper›PMID 38969500›Full record

ArticleeNeuro2024

Impact of Unitary Synaptic Inhibition on Spike Timing in Ventral Tegmental Area Dopamine Neurons.

Matthew H Higgs, Michael J Beckstead

Abstract read
In one paragraph

Article in eNeuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Alzheimer's Pathology Enhances Excitatory Synaptic Input and Integration in VTA Dopamine Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew H HiggsAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104 matthew-higgs@omrf.org.
Michael J BecksteadAging & Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104.

Funding

Contribution of locus coeruleus-derived galanin to opioid reward and reinforcementR01DA049257 · NIDA · EMORY UNIVERSITY · PI WEINSHENKER, DAVID · 2020 to 2024
$2.3M
Plasticity of GABA input to VTA dopamine neurons in opioid use disordersI01BX005396 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI BECKSTEAD, MICHAEL J · 2022 to 2025
–
BLRD VA I01 BX005396NIDA NIH HHS R01 DA049257
6 · The paper itself

Abstract

Midbrain dopamine neurons receive convergent synaptic input from multiple brain areas, which perturbs rhythmic pacemaking to produce the complex firing patterns observed in vivo. This study investigated the impact of single and multiple inhibitory inputs on ventral tegmental area (VTA) dopamine neuron firing in mice of both sexes using novel experimental measurements and modeling. We first measured unitary inhibitory postsynaptic currents produced by single axons using both minimal electrical stimulation and minimal optical stimulation of rostromedial tegmental nucleus and ventral pallidum afferents. We next determined the phase resetting curve, the reversal potential for GABA

Indexed as

Action PotentialsDopaminergic NeuronsInhibitory Postsynaptic PotentialsNeural InhibitionVentral Tegmental AreaAnimalsElectric StimulationFemaleMaleMiceMice, Inbred C57BLModels, Neurologicaldopamineinhibitionphase resettingspike timingunitary synaptic currentventral tegmental area

Identifiers

PMID38969500
PMCPMC11287791

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.